广角SS-OCT En Face结构投射图揭示未成年人玻璃体早期液化特征  

Wide-angle SS-OCT en face structural projection images reveal early vitreous liquefaction characteristics in minors

作　　者：邓飞[1] 周立军 陶梦颖 林英[1] 黄创新[1] 罗燕[1] DENG Fei;ZHOU Lijun;TAO Mengying;LIN Ying;HUANG Chuangxin;LUO Yan(State Key Laboratory of Ophthalmology,Zhongshan Ophthalmic Center,Sun Yat-sen University,Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science,Guangzhou 510060,China)

机构地区：[1]中山大学中山眼科中心,眼病防治全国重点实验室,广东省眼科视觉科学重点实验室,广州510060

出　　处：《眼科学报》2024年第10期533-540,共8页Eye Science

摘　　要：目的:应用广角扫频源光学相干断层扫描成像(swept-source optical coherence tomography,SS-OCT)的en face结构投射图研究玻璃体早期液化特征。方法:使用SS-OCT进行18 mm×18 mm的容积(Cube)扫描,创建并分析健康未成年人(年龄5~18岁)70眼的系列玻璃体en face结构投射图。结果:在未成年人中,视网膜前的玻璃体包含4种液化结构,分别为后皮质前玻璃体囊袋(posterior precortical vitreous pocket,PPVP)、视盘前Martegiani区(the area of Martegiani,AM)、血管前液化裂隙(prevascular vitreous fissures,PVF)和液化池(cistern)。所有研究眼均能检出PPVP、AM和PVF,其中22眼(31.4%)的PPVP和AM连通。41眼(58.6%)可检出液化池,且其年龄大于未检出液化池的个体(P=0.01),液化池的发生与年龄呈正相关(r_(s)=0.315,P=0.008)。液化池的象限空间分布频率依次为颞上(90.2%)、鼻上(58.5%)、颞下(36.6%)、鼻下(24.4%),最常累及颞上象限(P<0.001)。结论:PPVP、AM和PVF是健康人群视网膜前玻璃体早期液化过程中均出现的特征。液化池的发生与年龄呈正相关,最常出现在颞上象限,可能是年龄相关性玻璃体液化变性的结果。Objective:To investigate the early vitreous liquefaction characteristics using en face structural projection images obtained by wide-angle swept-source optical coherence tomography(SS-OCT).Methods:SS-OCT was employed to perform 18*18mm volumetric(Cube)scans.A series of en face structural projection images of the vitreous were created and analyzed for 70 eyes from healthy minors aged between 5 and 18 years.Results:In minors,four types of vitreous liquefaction structures were identified anterior to the retina:pre-posterior vitreous pocket(PPVP),the preoptic area of Martegiani(AM),pre-vascular liquefaction fissures(PVF),and cisterns.PPVP,AM,and PVF were detectable in all studied eyes,with PPVP and AM being interconnected in 22 eyes(31.4%).Cisterns were observed in 41 eyes(58.6%),and the mean age of individuals with cisterns was higher than those without(P=0.01).The occurrence of cisterns positively correlated with age(r=0.315;P=0.008).The frequency of cistern quadrant distribution was highest in the superotemporal quadrant(90.2%),followed by the superonasal quadrant(58.5%),inferotemporal quadrant(36.6%),and inferonasal quadrant(24.4%).The superotemporal quadrant was the most frequently affected(P<0.001).Conclusion:PPVP,AM,and PVF are features consistently observed in the early vitreous liquefaction process anterior to the retina in healthy individuals.The occurrence of cisterns positively correlates with age and is most common in the superotemporal quadrant,possibly representing the result of age-related vitreous liquefaction degeneration.These findings provide a theoretical foundation for studying the pathogenesis of vitreoretinal interface diseases.

关 键 词：扫频源光学相干断层扫描成像 en face结构投射图 玻璃体液化 液化池 玻璃体后脱离 

分 类 号：R779.7[医药卫生—眼科] R776.4[医药卫生—临床医学]