深研中国原创古今品种,推动临终关怀用药中国方案  

Study on traditional Chinese medicine and original Chinese drugs,promote new paradigms for drug development of China's hospice care

作　　者：张红娟 林媛 孙忠杰 高天乐 韩燕星[1] 蒋建东[1] ZHANG Hong-juan;LIN Yuan;SUN Zhong-jie;GAO Tian-le;HAN Yan-xing;JIANG Jian-dong

机构地区：[1]中国医学科学院北京协和医学院药物研究所,北京100050 [2]诺未科技(北京)有限公司,北京100176

出　　处：《中国医药生物技术》2024年第6期554-562,共9页Chinese Medicinal Biotechnology

基　　金：中国工程院战略研究与咨询资助项目(2023-XZ-88);国家自然科学基金面上项目(82374061)。

摘　　要：随着中国人口老龄化加剧,老年人慢病和癌症高发。老年慢病及癌症生命终末期患者面临着严重的经济压力,对临终关怀服务的迫切需求应受到社会重视。临终关怀用药作为提升生命终末期尊严和生存质量的重要手段,其研究在西方国家起步早,而我国近年来重视程度也在迅速提升。本文从药学工作角度出发,探讨了临终关怀期病人用药面临的管理机制和药物研发问题。通过调研临终关怀发展状况、临终关怀用药种类、药物研发政策,就如何调整临终关怀期病人用药范围,以更好服务于病患展开讨论。同时,发现中国特色用药包括中药及副作用较小的中国原创药,可以在临终关怀用药中发挥重要作用。借鉴西药成功经验,开发中国原创危重症用药,创新管理体制机制,推动临终关怀用药研究中国方案,是中国新药创制重要的新范式,有望促进我国临终关怀事业健康持续发展。As China's population ages,the incidence of chronic diseases and cancer among the elderly is increasing.Elderly patients with chronic diseases and cancer at the end of life face significant economic pressure,and their urgent need for hospice care service should be valued by the society.Medications used in hospice care play a crucial role to meet the needs of dignity and quality of life during the terminal stage.While the study of hospice drugs started early in Western countries,China has also been paying increasing attention to it in recent years.This paper explores the issues of prescription management and new drug development in hospice care from the standpoint of pharmaceutical science and its applications.By investigating the development status of hospice care,the types of hospice drugs,and the policies related to drug research and development,we discuss how to adjust the selection of drugs for patients in hospice care to better serve them.Examples of hospice drugs from both ancient and modern times are presented,indicating that traditional Chinese medicine and original Chinese drugs with minimal side effects can play a significant role in hospice care.By learning from the successful experience of Western medicine,developing original Chinese medications specifically for the treatment of critical illnesses,innovating the management mechanism,and promoting the Chinese approach of hospice medicine research,we can establish important new paradigms for new drug development in China.

关 键 词：临终关怀 姑息性治疗 传统中药 新药 体制创新 

分 类 号：R48[医药卫生—临床医学]