黄酮类化合物合成生物体系构建的研究进展  

Advancements in constructing biological systems for flavonoid synthesis

作　　者：王若彤 沈晓凤 严赵玖 孙超[1] 李滢[1] WANG Ruo-tong;SHEN Xiao-feng;YAN Zhao-jiu;SUN Chao;LI Ying

机构地区：[1]中国医学科学院北京协和医学院药用植物研究所鉴定中心,北京100193

出　　处：《中国医药生物技术》2024年第6期569-576,共8页Chinese Medicinal Biotechnology

基　　金：中国医学科学院医学与健康科技创新工程(2021-I2M-1-032)。

摘　　要：黄酮是一类广泛存在于植物中的次生代谢产物,具有抗炎、抗癌、抗心血管疾病、抗糖尿病、抗衰老和辐射防护等多种药理活性。目前,黄酮类化合物生产主要依赖于植物提取和化学合成,但难以满足市场需求。因此,采取微生物合成天然产物为其大规模生产提供了新的方法。本文综述了在黄酮类化合物生产中,构建微生物细胞工厂的策略,并整理了近些年通过合成生物学生产黄酮类化合物的相关实例,为黄酮类化合物的合成生物学研究提供参考。Flavonoids,widely present secondary metabolites found in plants,exhibit a spectrum of pharmacological activities,including anti-inflammatory,anti-cancer,anti-cardiovascular disease,anti-diabetes,anti-aging and radiation protection properties.Currently,the production of flavonoids primarily relies on plant extraction and chemical synthesis,which may not be able to meet the market demand.As a result,microbial synthesis of natural products has emerged as a novel approach for achieving their large-scale production.In the paper,we review the strategies for constructing microbial cell factories in flavonoid production and compile relevant examples of flavonoid production through synthetic biology in recent years,providing a valuable reference for synthetic biology research on flavonoids.

关 键 词：黄酮类化合物 生物合成 细胞工厂 代谢调控 

分 类 号：R914[医药卫生—药物化学]