Neuroform支架与LVIS/LVIS Jr支架联合弹簧圈栓塞术治疗颅内动脉瘤患者的效果对比  

Comparison of Effect of Neuroform Stent and LVIS/LVIS Jr Stent Combined with Spring Coil Embolization on Patients with Intracranial Aneurysm

作　　者：张磊[1] ZHANG Lei(Department of Neurosurgery,Rongcheng People’s Hospital,Rongcheng 264300,China)

机构地区：[1]山东省荣成市人民医院神经外科,山东荣成264300

出　　处：《中国伤残医学》2024年第16期86-89,共4页Chinese Journal of Trauma and Disability Medicine

摘　　要：目的:探讨Neuroform支架与LVIS/LVIS Jr支架联合弹簧圈栓塞术对颅内动脉瘤(IA)患者脑血流灌注指标及预后的影响。方法:回顾性分析2021年9月—2022年12月荣成市人民医院108例IA患者的临床资料,按照手术所用支架的不同分为对照组与研究组,各54例。对照组采用Neuroform支架联合弹簧圈栓塞术治疗,研究组采用LVIS/LVIS Jr支架联合弹簧圈栓塞术治疗。比较两组脑血流灌注指标、神经营养标志物水平、远期预后及并发症发生情况。结果:术后1周,两组患侧局部颅内压(ICP)均低于术前,脑血容量(rCBV)均高于术前,且研究组ICP低于对照组,rCBV高于对照组,差异均有统计学意义(P<0.05)。术后1周,两组S-100B蛋白、神经生长因子(NGF)水平均低于术前,且研究组S-100B蛋白、NGF水平低于对照组,差异均有统计学意义(P<0.05)。术后1年,研究组改良Rankin量表评分、动脉瘤血管再通率均低于对照组,差异均有统计学意义(P<0.05)。术后1年,研究组支架内血栓发生率低于对照组,差异有统计学意义(P<0.05),脑血管痉挛、载瘤动脉狭窄、弹簧圈逃逸的发生率比较,差异均无统计学意义(P>0.05)。结论:采用LVIS/LVIS Jr支架联合弹簧圈栓塞术治疗IA患者,可改善脑血流灌注指标、神经营养标志物水平、远期预后,降低支架内血栓发生率。Objective:To investigate the effects of Neuroform stent and LVIS/LVIS Jr stent combined with coil embolization on cerebral blood perfusion indexes and prognosis of patients with intracranial aneurysm(IA).Methods:The clinical data of 108 patients with IA in Rongcheng People’s Hospital from September 2021 to December 2022 were retrospectively analyzed,and they were divided into a control group and a study group according to the different stents used in surgery,with 54 cases in each group.The control group was treated with Neuroform stent combined with coil embolization,and the study group was treated with LVIS/LVIS Jr stent combined with coil embolization.Cerebral blood perfusion indexes,neurotrophic markers,long-term prognosis and complications were compared between the two groups.Results:One week after surgery,the local intracranial pressure(ICP)and cerebral blood volume(rCBV)of the affected side were all lower than before surgery,and the ICP of the study group was lower than that of the control group,and the rCBV of the control group was higher,with statistical significance(P<0.05).One week after surgery,the levels of S-100B protein and nerve growth factor(NGF)in two groups were lower than before surgery,and the levels of S-100B protein and NGF in the study group were lower than those in the control group,with statistical significance(P<0.05).One year after surgery,the modified Rankin scale score and aneurysm revascularization rate in the study group were lower than those in the control group,with statistical significance(P<0.05).One year after surgery,the incidence of stent thrombosis in the study group was lower than that in the control group,the difference was statistically significant(P<0.05),and the incidence of cerebral vasopost tumor bearing artery stencs and coil escape were not statistically significant(P>0.05).Conclusion:The combination of LVIS/LVIS Jr stent and coil embolization in the treatment of IA patients can improve cerebral blood perfusion indexes,neurotrophic markers,long-term prognosis,redu

关 键 词：颅内动脉瘤 NEUROFORM支架 LVIS/LVISJr支架 弹簧圈栓塞术 脑血流灌注 预后 

分 类 号：R739.41[医药卫生—肿瘤]