固定化ACE及其应用于分离和富集食源性ACE抑制肽的研究进展  

Research progress on ACE immobilization and immobilized ACE used for affinity separation and enrichment of food-derived antihypertensive peptides

作　　者：张婧婧 刘智禹[2,3,4] ZHANG Jingjing;LIU Zhiyu(Zhangzhou College of Science and Technology,Zhangzhou,Fujian 363202,China;Fishries Research Institute of Fujian,Xiamen,Fujian 361013,China;National Research and Development Center for Marine Fish Processing(Xiamen),Xiamen,Fujian 361013,China;Key Laboratory of Cultivation and High-value Utilization of Marine Organisms in Fujian Province,Xiamen,Fujian 361013,China)

机构地区：[1]漳州科技职业学院,福建漳州363202 [2]福建省水产研究所,福建厦门361013 [3]国家海水鱼类加工技术研发分中心(厦门),福建厦门361013 [4]福建省海洋生物增养殖与高值化利用重点实验室,福建厦门361013

出　　处：《食品与机械》2024年第10期218-226,共9页Food and Machinery

基　　金：福建省科技厅星火项目(编号:2021S0051);漳州市自然基金项目(编号:ZZ2023J22)。

摘　　要：血管紧张素转换酶(angiotensinⅠ-converting enzyme,ACE)在血压调节中起关键作用,抑制ACE活性可控制血压升高,食源性ACE抑制肽(angiotensin-Ⅰconverting enzyme inhibitory peptide,ACEIP)因其降压作用温和专一与高安全性近些年受到广泛关注与研究。通过ACE的固定化可以克服传统游离ACE的不足并显著提高其稳定性,并赋予较好的重复使用性。文章对ACE的固定化与固定化ACE用作选择性富集食源性ACEIP组分的亲和分离介质等方面的相关研究进行了综述,并展望了其工业化应用前景。Food-derived ACE inhibitory peptides can regulate blood pressure mildly and specifically by inhibiting the activity of ACE,which has attracted widespread attention and extensive research.Immobilization of ACE can overcome the shortcomings of traditional free ACE,significantly improve its stability,and give better reusability.This review summarized the immobilization of ACE and its use as an affinity separation medium for selective enrichment of food-borne ACEIP components,and prospects for its industrial application.

关 键 词：固定化ACE 食源性ACE抑制肽 亲和型分离介质 选择性富集 

分 类 号：TS201.2[轻工技术与工程—食品科学]