TgAb、TPOAb在分化型甲状腺癌患者血清中的表达及与中央区淋巴结转移的关系  

Expression of Serum TgAb and TPOAb in Differentiated Thyroid Carcinoma Patients and Their Relationship with Central Lymph Node Metastasis

作　　者：焦东晓 冀峰 吕复君 王西礼 JIAO Dongxiao;JI Feng;LV Fujun(Kaifeng Central Hospital,Kaifeng,475000)

机构地区：[1]河南省开封市中心医院,475000

出　　处：《实用癌症杂志》2024年第12期1956-1960,共5页The Practical Journal of Cancer

摘　　要：目的探讨TgAb、TPOAb在分化型甲状腺癌患者血清中的表达及与中央区淋巴结转移的关系。方法选取分化型甲状腺癌患者100例纳入观察组,同时期选取健康志愿者50名纳入对照组,比较2组患者血清TgAb、TPOAb水平。分析影响中央区淋巴结转移的因素,ROC曲线分析血清TgAb、TPOAb水平预测分化型甲状腺癌中央区淋巴结转移的价值。结果观察组患者血清TgAb、TPOAb水平均高于对照组,差异均具有统计学意义(P<0.05)。中央区淋巴结转移患者共56例,未出现转移患者共44例。转移组与未转移组在肿瘤大小、TgAb、TPOAb、肿瘤是否多灶性、肿瘤是否双侧性等方面比较,差异均具有统计学意义(P<0.05),2组在年龄、性别、是否神经侵犯、是否血管侵犯、术前TSH水平、组织学分类等方面比较,差异均无统计学意义(P>0.05)。多因素分析结果发现,肿瘤多灶性、双侧性、TGAb高表达、TPOAb高表达以及术前TSH降低是影响中央区淋巴结转移的独立危险因素(P<0.05)。血清TgAb、TPOAb水平及两者联合预测分化型甲状腺癌中央区淋巴结转移AUC分别为0.771、0.752、0.819,联合预测的敏感度84.9%、特异度89.8%,均高于单一预测(P<0.05)。结论分化型甲状腺癌患者血清TgAb、TPOAb水平明显上调,其高表达均是中央区淋巴结转移的独立危险因素。Objective To investigate the expression of serum TgAb and TPOAb in differentiated thyroid carcinoma patients and its relationship with central lymph node metastasis.Methods A total of 100 patients with differentiated thyroid cancer were selected as the observation group,and 50 healthy volunteers were selected as the control group at the same time.The serum TgAb and TPOAb levels were compared between the 2 groups.The influencing factors of central lymph node metastasis were analyzed.ROC curve was used to analyze the value of serum TgAb and TPOAb levels in predicting central lymph node metastasis of differentiated thyroid cancer.Results The serum levels of TgAb and TPOAb in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).There were 56 patients with central lymph node metastasis and 44 patients without central lymph node metastasis.There were significant differences between the metastasis group and the non-metastasis group in tumor size,TgAb,TPOAb,whether the tumor was multifocal,and whether the tumor was bilateral(P<0.05).There were no significant differences in age,gender,nerve invasion,vascular invasion,preoperative TSH level,and histological classification between the 2 groups(P>0.05).The results of multivariate analysis showed that multifocality,bilaterality,high expression of TGAb,high expression of TPOAb,and low preoperative TSH were independent risk factors for central lymph node metastasis(P<0.05).The AUC of serum TgAb,TPOAb levels and their combination in predicting central lymph node metastasis of differentiated thyroid cancer were 0.771,0.752 and 0.819,respectively.The sensitivity and specificity of combined prediction were 84.9%and 89.8%,which were higher than those of single prediction(P<0.05).Conclusion Serum TgAb and TPOAb levels are significantly up-regulated in differentiated thyroid carcinoma patients,and their high expression is an independent risk factor for central lymph node metastasis.

关 键 词：TGAB TPOAB 分化型甲状腺癌 中央区淋巴结转移 临床意义 

分 类 号：R736.1[医药卫生—肿瘤]