MIP-1α、S-TK1在分化型甲状腺癌患者中的表达及意义  

Expression and Significance of MIP-1αand S-TK1 in Differentiated Thyroid Carcinoma Patients

作　　者：李亮 邱福轩 刘光辉 梁百闯 LI Liang;QIU Fuxuan;LIU Guanghui(Jiaozuo Coal Industry(Group)Co.,Ltd.Central Hospital,Jiaozuo,454000)

机构地区：[1]焦作煤业(集团)有限责任公司中央医院,454000

出　　处：《实用癌症杂志》2024年第12期1961-1965,共5页The Practical Journal of Cancer

摘　　要：目的探讨MIP-1α、S-TK1在分化型甲状腺癌患者中的表达及意义。方法选取86例分化型甲状腺癌患者纳入观察组,同时术中留取患者癌组织和癌旁组织(距离癌组织2 cm以上)。同时期选取正常健康人30名纳入对照组。酶联免疫吸附试验检测血清MIP-1α、S-TK1水平,采用免疫组织化学染色法检测癌组织和癌旁组织中MIP-1α、S-TK1蛋白表达。统计血清MIP-1α、S-TK1在分化型甲状腺癌中的表达及诊断价值。结果观察组血清MIP-1α、S-TK1水平均高于对照组(P<0.05),癌组织中MIP-1α、S-TK1蛋白阳性表达均高于癌旁组织(P<0.05)。以MIP-1α、S-TK1水平均数作为临界值,将MIP-1α≥71.16 ng/L纳入高表达组,反之纳入低表达组;将S-TK1≥6.59 pmol/L纳入高表达组,反之纳入低表达组。血清MIP-1α、S-TK1水平高表达组与低表达组在TNM分期、淋巴结转移方面比较,差异有统计学意义(P<0.05)。Pearson相关性分析显示,分化型甲状腺癌患者血清MIP-1α与S-TK1水平呈正相关(γ=0.645,P=0.000)。血清MIP-1α、S-TK1及联合检测AUC(OR)分别为0.853(0.821~0.889)、0.817(0.758~0.736)、0.913(0.903~0.961),且联合检测价值均高于单一检测(P<0.05)。结论MIP-1α、S-TK1水平在分化型甲状腺癌患者中高表达,且两者呈正相关性。血清MIP-1α、S-TK1联合检测有助于提高分化型甲状腺癌的诊断价值。Objective To investigate the expression relationship and significance of MIP-1αand S-TK1 in differentiated thyroid carcinoma patients.Methods 86 patients with differentiated thyroid cancer were selected as the observation group,and the cancer tissues and adjacent tissues(more than 2 cm away from the cancer tissue)were collected during the operation.At the same time,30 normal healthy people were selected as the control group.The serum levels of MIP-1αand S-TK1 were detected by enzyme-linked immunosorbent assay.The protein expressions of MIP-1αand S-TK1 in cancer tissues and adjacent tissues were detected by immunohistochemical staining.The expression and diagnostic value of serum MIP-1αand S-TK1 in differentiated thyroid carcinoma were analyzed.Results The serum levels of MIP-1αand S-TK1 in the observation group were higher than those in the control group(P<0.05).The positive expressions of MIP-1αand S-TK1 proteins in cancer tissues were higher than those in adjacent tissues(P<0.05).Taking the mean level of MIP-1αand S-TK1 as the critical value,MIP-1α≥71.16 ng/L was included in the high expression group,otherwise was included in the low expression group;Patients with S-TK1≥6.59 pmol/L were included in the high expression group,otherwise were included in the low expression group.There were significant differences in TNM stage and lymph node metastasis between the high expression group and the low expression group of serum MIP-1αand S-TK1(P<0.05).Pearson correlation analysis showed that serum MIP-1αlevel was positively correlated with S-TK1 level in patients with differentiated thyroid cancer(γ=0.645,P=0.000).The AUC(OR)of serum MIP-1α,S-TK1 and combined detection were 0.853(0.821~0.889),0.817(0.758~0.736)and 0.913(0.903~0.961),respectively,and the combined detection value was higher than that of single detection(P<0.05).Conclusion Serum MIP-1αand S-TK1 are highly expressed in differentiated thyroid carcinoma patients,and they are positively correlated.Combined detection is helpful to improve the di

关 键 词：分化型甲状腺癌 MIP-1Α S-TK1 临床意义 

分 类 号：R736.1[医药卫生—肿瘤]