老年胃癌患者血清中PARP1、HGF、APF表达水平与肿瘤侵袭、转移的关系  

The Relationship Between the Expression Levels of PARP1,HGF and APF in Serum of Elderly Patients with Gastric Cancer and Tumor Invasion and Metastasis

作　　者：张袁丹 祝丽双 高培 ZHANG Yuandan;ZHU Lishuang;GAO Pei(The Fifth Clinical Medical College of Henan University of Chinese Medicine(Zhengzhou People's Hospital),Zhengzhou,450000)

机构地区：[1]河南中医药大学第五临床医学院,郑州人民医院,450000

出　　处：《实用癌症杂志》2024年第12期1973-1975,1979,共4页The Practical Journal of Cancer

摘　　要：目的探究老年胃癌患者血清中聚腺苷酸二磷酸核糖聚合酶1(PARP1)、肝细胞生长因子(HGF)、甲胎蛋白(AFP)表达水平与肿瘤侵袭、转移的关系。方法采取回顾性分析法。选取老年胃癌患者共计198例,均接受PARP1、HGF、APF指标的检测;通过查阅患者电子病历以及医院信息系统(HIS)数据库收集患者血清学检测结果以及基线资料。根据胃癌患者在确诊后1年内的肿瘤侵袭、转移情况分为严重侵袭转移组(n=71)、可控侵袭转移组(n=127),比较2组研究对象的PARP1、HGF水平、APF阳性表达率;随后采用Logistic多因素回归分析评估上述影响因素与老年胃癌患者肿瘤侵袭、转移之间的相关性。结果严重侵袭转移组患者的PARP1、HGF水平显著高于可控侵袭转移组,差异存在统计学意义(P<0.05);严重侵袭转移组患者的APF表达阳性率显著高于可控侵袭转移组,差异同样存在统计学意义(P<0.05)。多因素回归分析结果显示,胃癌患者PARP1、HGF水平与肿瘤侵袭转移呈正相关;APF阳性表达是肿瘤出现严重侵袭、转移的独立危险因素(P<0.05)。结论老年胃癌患者PARP1、HGF高水平表达以及APF阳性表达与肿瘤侵袭、转移情况之间存在正相关,对预测胃癌患者疾病发展进程具有较高的参考价值。Objective To explore the relationship between the expression levels of poly(ADP-ribose)polymerase 1(PARP1),hepatocyte growth factor(HGF)and alpha-fetoprotein(AFP)in serum of elderly patients with gastric cancer and tumor invasion and metastasis.Methods Retrospective analysis was adopted.A total of 198 elderly patients with gastric cancer were selected and tested for PARP1,HGF and APF.The serological test results and baseline data of patients were collected by consulting the patient's electronic medical records and the hospital information system(HIS)database.According to the tumor invasion and metastasis of gastric cancer patients within 1 year after diagnosis,they were divided into severe invasion and metastasis group(n=71)and controllable invasion and metastasis group(n=127).The levels of PARP1,HGF and the positive expression rate of APF were compared between the 2 groups.Logistic multivariate regression analysis was used to evaluate the correlation between the above influencing factors and tumor invasion and metastasis in elderly patients with gastric cancer.Results The levels of PARP1 and HGF in the severe invasion and metastasis group were significantly higher than those in the controllable invasion and metastasis group,and the differences were statistically significant(P<0.05).In addition,the positive rate of APF expression in patients with severe invasion and metastasis was significantly higher than that in the controllable invasion and metastasis group,and the difference was also statistically significant(P<0.05).Multivariate regression analysis showed that the levels of PARP1 and HGF in patients with gastric cancer were positively correlated with tumor invasion and metastasis.The positive expression of APF was an independent risk factor for severe invasion and metastasis of tumor(P<0.05).Conclusion The high expression of PARP1,HGF and the positive expression of APF in elderly patients with gastric cancer are positively correlated with tumor invasion and metastasis,which has a high reference value for pre

关 键 词：胃癌 聚腺苷酸二磷酸核糖聚合酶1 肝细胞生长因子 甲胎蛋白 肿瘤侵袭转移 老年患者 

分 类 号：R735.2[医药卫生—肿瘤]