孕激素与根治性子宫切除及双侧附件切除术对子宫内膜癌患者的肿瘤标志物及生活质量的影响  

Effects of Progesterone,Radical Hysterectomy and Bilateral Adnexectomy on Tumor Markers and Quality of Life in Patients with Endometrial Cancer

作　　者：马竹青[1] 王瑞芳[1] 郭燕[1] MA Zhuqing;WANG Ruifang;GUO Yan(The First Affiliated Hospital of Henan University of Science and Technology,Luoyang,471003)

机构地区：[1]河南科技大学第一附属医院,471003

出　　处：《实用癌症杂志》2024年第12期2004-2007,共4页The Practical Journal of Cancer

基　　金：河南省医学科技攻关计划项目(编号:LHGJ20210595)。

摘　　要：目的探讨孕激素与根治性子宫切除及双侧附件切除术对子宫内膜癌患者的肿瘤标志物及生活质量的影响。方法选取81例子宫内膜癌患者,依照治疗方法的不同分组,采用根治性子宫切除及双侧附件切除术治疗的37例作为对照组,采用孕激素与根治性子宫切除及双侧附件切除术治疗的44例作为观察组。比较2组治疗效果、肿瘤标志物水平、生活质量评分及不良反应发生情况。结果观察组客观有效率(93.18%)高于对照组(75.68%),差异有统计学意义(χ^(2)=4.881,P=0.027)。治疗前,2组HE4、CEA水平差异不显著(P>0.05),治疗后2组HE4、CEA水平均显著降低(P均<0.05),且观察组低于对照组(P均<0.05)。治疗前,2组生活质量评分差异无统计学意义(P>0.05),治疗后2组生活质量评分显著提升(P均<0.05),且观察组高于对照组(t=3.972,P=0.000)。观察组不良反应总发生率(4.55%)低于对照组(21.62%),差异有统计学意义(χ^(2)=3.953,P=0.047)。结论孕激素与根治性子宫切除及双侧附件切除术联合治疗能够改善对子宫内膜癌的治疗效果,降低肿瘤标志物水平,提升患者生活质量,降低不良事件的发生率。Objective To investigate the effects of progesterone,radical hysterectomy and bilateral adnexectomy on tumor markers and quality of life in patients with endometrial cancer.Methods A total of 81 patients with endometrial carcinoma were selected,and 37 patients with radical hysterectomy and bilateral adnexectomy were selected as the control group,and 44 patients with progesterone and radical hysterectomy and bilateral adnexectomy were selected as the observation group.The therapeutic effect,tumor marker level,quality of life score and adverse reactions were compared between the 2 groups.Results The effective rate of the observation group(93.18%)was higher than that of the control group(75.68%),and the difference was statistically significant(χ^(2)=4.881,P=0.027).Before treatment,there were no significant differences in HE4 and CEA levels between the 2 groups(P>0.05),but after treatment,HE4 and CEA levels were significantly decreased between the 2 groups(P<0.05),and the observation group was lower than the control group(P<0.05).Before treatment,there was no statistical difference in QOL score between the 2 groups(P>0.05),but after treatment,QOL score between the 2 groups was significantly improved(P<0.05),and the observation group was higher than the control group(t=3.972,P=0.000).The total incidence of adverse reactions in the observation group(4.55%)was lower than that in the control group(21.62%),and the difference was statistically significant(χ^(2)=3.953,P=0.047).Conclusion Progesterone,radical hysterectomy and bilateral adnexectomy can improve the treatment effect of endometrial cancer,reduce the level of tumor markers,improve the quality of life of patients,and reduce the incidence of adverse events.

关 键 词：孕激素 根治性子宫切除术 双侧附件切除术 子宫内膜癌 肿瘤标志物 生活质量 

分 类 号：R737.33[医药卫生—肿瘤]