三维适形放疗联合立体定向放疗治疗原发性肝癌的近期疗效及安全性  

The Short-term Efficacy and Safety of Three-dimensional Conformal Radiotherapy Combined with Stereotactic Radiotherapy for Primary Liver Cancer

作　　者：刘苗苗 陈晓亮 李晶[2] 穆振诺 LIU Miaomiao;CHEN Xiaoliang;LI Jing(General Hospital of Pingmei Shenma Group,Pingdingshan,467000)

机构地区：[1]平煤神马医疗集团总医院,467000 [2]湖北文理学院附属襄阳中心医院,441100 [3]山东省烟台市烟台山医院,264000

出　　处：《实用癌症杂志》2024年第12期2043-2047,共5页The Practical Journal of Cancer

摘　　要：目的探讨三维适形放疗联合立体定向放疗治疗原发性肝癌的近期疗效,并分析其安全性。方法依据随机数字表法将96例原发性肝癌患者分为对照组和观察组,各48例。对照组给予立体定向放疗治疗,观察组在对照组基础上加用三维适形放疗治疗。比较2组临床疗效、血清肿瘤标志物、肝功能及放射性不良反应,并随访至2023年5月统计2组生存情况。结果观察组临床缓解率高于对照组,且观察组血清糖类抗原19-9、甲胎蛋白、α-L-岩藻糖苷酶、癌胚抗原、谷丙转氨酶、谷草转氨酶、总胆红素水平均低于对照组(P<0.05);2组放疗期间放射性不良反应发生率比较,差异无统计学意义(P>0.05)。随访期间,观察组生存时间长于对照组(P<0.05)。结论三维适形放疗联合立体定向放疗可提高原发性肝癌的治疗效果,降低血清肿瘤标志物水平,改善患者肝功能,还可延长患者生存时间,且不会增加放射性不良反应。Objective To explore the short-term efficacy of three-dimensional conformal radiotherapy combined with stereotactic radiotherapy in the treatment of primary liver cancer,and to analyze its safety.Methods According to the random number table method,96 patients with primary liver cancer were divided into a control group and an observation group,with 48 patients in each group.The control group received stereotactic radiotherapy,while the observation group received three-dimensional conformal radiotherapy in addition to the control group.The clinical efficacy,serum tumor markers,liver function and radioactive adverse reactions were compared between the 2 groups,and the survival of the 2 groups was followed up to May 2023.Results The clinical remission rate of the observation group was higher than that of the control group,and the levels of serum carbohydrate antigen 19-9,alpha-fetoprotein,α-L-fucosidase,carcinoembryonic antigen,alanine aminotransferase,aspartate aminotransferase and total bilirubin in the observation group were lower than those in the control group(P<0.05).There was no statistical significant difference in the incidence of radiation adverse reactions between the 2 groups during radiotherapy(P>0.05).During the follow-up period,the observation group had a longer survival time than the control group(P<0.05).Conclusion The combination of three-dimensional conformal radiotherapy and stereotactic radiotherapy can improve the treatment effect of primary liver cancer,reduce serum tumor marker levels,improve liver function,and prolong patient survival time without increasing radiation adverse reactions.

关 键 词：原发性肝癌 立体定向放疗 三维适形放疗 近期疗效 安全性 

分 类 号：R735.7[医药卫生—肿瘤]