放射性颌骨坏死治疗策略研究进展  

Research progress of treatment strategies for osteoradionecrosis of the jaws

作　　者：王希锐 朱慧勇[1] WANG Xirui;ZHU Huiyong(Department of Oral and Maxillofacial Surgery,the First Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310058,China)

机构地区：[1]浙江大学医学院附属第一医院口腔颌面外科,浙江杭州310058

出　　处：《口腔医学》2024年第11期864-870,共7页Stomatology

基　　金：国家自然科学基金(31570989)。

摘　　要：头颈部恶性肿瘤是全球范围内的第七大常见肿瘤,约占全部恶性肿瘤的10%,放射治疗是头颈部恶性肿瘤的重要治疗方案。放射性颌骨坏死(osteoradionecrosis of the jaws,ORNJ)是一种头颈部恶性肿瘤放疗后出现的难治并发症,常表现出颌骨坏死和软组织暴露。当前ORNJ的发病机制尚未完全明确,其治疗仍具有挑战性。该病传统的治疗方式为部分切除坏死颌骨结合骨皮瓣重建。但近年来,一些新技术、新思路被用于治疗该疾病,对于程度较轻的放射性颌骨坏死,治疗理念趋于保守。本文主要归纳国内外最新研究进展,对放射性颌骨坏死的发病机制、临床表现和治疗策略进行综述。Head and neck cancer is the seventh most common cancer in the world,accounting for about 10%of all malignant tumors.Radiotherapy is an important treatment for head and neck cancer.Osteonecrosis of the jaws(ORNJ)is a refractory complication after radiotherapy for head and neck cancer,which often manifests as osteonecrosis of the jaw and soft tissue exposure.The current pathogenesis of ORNJ has not been fully clarified and its treatment remains challenging.The traditional treatment for this disease is partial resection of necrotic jaw bone and reconstruction with osteocutaneous flap.However,in recent years,some new techniques and ideas have been used to treat the disease.For mild osteoradionecrosis of the jaw,the treatment concept tends to be conservative.This article mainly summarizes the latest research progress at home and abroad,and reviews the pathogenesis,clinical manifestations and treatment strategies for osteoradionecrosis of the jaws.

关 键 词：放射性颌骨坏死 间充质干细胞 虚拟手术设计 

分 类 号：R782.32[医药卫生—口腔医学]