铜死亡在口腔鳞状细胞癌治疗及预后中的研究进展  

Research progress of cuproptosis in the treatment and prognosis of oral squamous cell carcinoma

作　　者：要甜 马宇锋 YAO Tian;MA Yufeng(School and Hospital of Stomatology,Shanxi Medical University,Taiyuan 030000,China)

机构地区：[1]山西医科大学口腔医学院,山西太原030000 [2]山西医科大学口腔医学院·山西医科大学第二医院口腔科,山西太原030000

出　　处：《口腔医学》2024年第11期871-875,共5页Stomatology

摘　　要：口腔鳞状细胞癌(oral squamous cell carcinoma,OSCC)是一种死亡率高的恶性肿瘤,其特点是诊断晚、复发转移率高、预后差。铜死亡(cuproptosis)作为一种新型的铜诱导细胞死亡的模式,激活相关通路能抑制癌细胞的生长和增殖,诱导癌细胞发生铜死亡为OSCC的治疗提供了新的见解。本综述旨在系统介绍铜死亡发生发展的机制以及铜死亡在OSCC治疗预后方面的研究进展,为临床治疗提供新的思路和方法。Oral squamous cell carcinoma(OSCC)is a malignant tumor with a high mortality rate,which is characterized by late diagnosis,high recurrence and metastasis rates,and poor prognosis.Cuproptosis,as a novel mode of cupric induced cell death,can inhibit the growth and proliferation of cancer cells by activating related pathways,which provides a new insight into the treatment of OSCC.This review aims to systematically introduce the mechanism of cuproptosis occurrence and development,as well as the research progress of cuproptosis in the prognosis of OSCC treatment.It provides new ideas and methods for clinical treatment.

关 键 词：口腔鳞状细胞癌 铜死亡 铁氧还蛋白1 蛋白质脂质 铜螯合物 lncRNA 三羧酸循环 

分 类 号：R780.2[医药卫生—口腔医学]