聚乳酸-羟基乙酸微球在口腔领域的研究进展  

Research progress of PLGA microspheres in stomatology

作　　者：李宇倩 江静 陈梦含 邵依倩 冯剑颖[1] LI Yuqian;JIANG Jing;CHEN Menghan;SHAO Yiqian;FENG Jianying(School of Stomatology,Zhejiang Chinese Medical University,Hangzhou 310053,China)

机构地区：[1]浙江中医药大学口腔医学院,浙江杭州310053

出　　处：《口腔医学》2024年第11期876-880,共5页Stomatology

基　　金：浙江省自然基金(TGY24H140010)。

摘　　要：聚乳酸-羟基乙酸[poly(lactic⁃co⁃glycolicacid),PLGA]载药微球相较于其他载药方式具有缓释控释能力、生物可降解性、释药稳定性、靶向传递功能等优势,日益成为药剂学领域的研究热点。随着微球制备技术的精进与微球产品质量的提高,其在临床中已逐步推广使用,对肿瘤、骨关节炎、糖尿病、眼部疾病等方面的治疗成效显著,但目前缺乏PLGA微球在口腔领域应用的系统综述。本文旨在介绍PLGA微球的临床应用特点,并对PLGA微球在口腔颌面部肿瘤、颞下颌关节疾病、牙周炎、龋病和牙槽骨缺损等疾病方面的应用前景进行综述,为其在口腔领域的应用提供参考。Compared with other drug loading methods,PLGA drug⁃loaded microspheres have the advantages of sustained and controlled release ability,biodegradability,drug release stability,and targeted delivery function,which have become a research hotspot in pharmaceutics.With the improvement of the preparation technology and the quality of microspheres,they have been gradually promoted in clinical practice,and have achieved remarkable results in the treatment of tumors,osteoarthritis,diabetes,eye diseases and so on.However,there is still a lack of systematic review on the application of PLGA microspheres in stomatology.This article aims to introduce the clinical application characteristics of PLGA microspheres,and review their application prospect in oral and maxillofacial tumors,temporomandibular joint diseases,periodontitis,caries and alveolar bone defects,so as to provide reference for their application in stomatology.

关 键 词：聚乳酸-羟基乙酸 微球 缓释 口腔 

分 类 号：R78[医药卫生—口腔医学]