Advancements in dental hard tissue restorative materials and challenge of clinical translation  

牙齿硬组织修复材料的研究进展及临床转化挑战

作　　者：Bowen Hu Yanyun Pang Xiaoxue Yang Kun Xuan Xu Zhang Peng Yang 胡博文;逄艳云;杨晓雪;轩昆;张旭;杨鹏

机构地区：[1]Key Laboratory of Applied Surface and Colloid Chemistry,Ministry of Education,School of Chemistry and Chemical Engineering,Shaanxi Normal University,Xi’an 710119,China [2]Tianjin Medical University School and Hospital of Stomatology&Tianjin Key Laboratory of Oral Soft and Hard Tissues Restoration and Regeneration,Tianjin 300070,China [3]State Key Laboratory of Oral&Maxillofacial Reconstruction and Regeneration,National Clinical Research Center for Oral Diseases,Shaanxi Clinical Research Center for Oral Disease,Department of Preventive Dentistry,School of Stomatology,The Fourth Military Medical University,Xi’an 710032,China [4]Xi’an Key Laboratory of Polymeric Soft Matter,School of Chemistry and Chemical Engineering,Shaanxi Normal University,Xi’an 710119,China [5]International Joint Research Center on Functional Fiber and Soft Smart Textile,School of Chemistry and Chemical Engineering,Shaanxi Normal University,Xi’an 710119,China [6]Tianjin Medical University Institute of Stomatology,Tianjin 300070,China [7]Department of Pediatric Dentistry,School and Hospital of Stomatology,Shandong University/Shandong Key Laboratory of Oral Tissue Regeneration/Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration/Shandong Provincial Clinical Research Center for Oral Diseases,Jinan 250012,China

出　　处：《Science China Materials》2024年第12期3811-3832,共22页中国科学（材料科学）（英文版）

基　　金：the funding from the National Science Fund for Distinguished Young Scholars(52225301);the National Key Research and Development Program of China(2020YFA0710400 and 2020YFA0710402);the 111 Project(B14041),the International Science and Technology Cooperation Program of Shaanxi Province(2022KWZ-24);the Fundamental Research Funds for the Central Universities(GK202305001 and GK202309034);the Key Science&Technology Innovation Team of Shaanxi Province(2022TD-35);the funding from the National Key Research and Development Program of China(2022YFC2405900 and 2022YFC2405902);the funding from the National Natural Science Foundation of China(82370949)。

摘　　要：Dental hard tissues,primarily enamel and dentin,serving essential functions such as cutting,chewing,speaking,and maintaining facial aesthetics,mainly composed well-aligned hydroxyapatite(HAp)nanocrystals interlaced with a protein matrix.These tissues exhibit remarkable mechanical and aesthetic behaviors.However,once damaged,its ability to self-repair is extremely limited,often accompanied by dentin hypersensitivity(DH).Currently,although dental restorations using synthetic materials and remineralization techniques have made clinical progress,these methods still have limitations that affect their widespread use in clinical applications.Therefore,understanding the formation mechanisms of dental hard tissues and developing high-performance restorative technologies that can mimic natural teeth and meet clinical needs are crucial.This review focuses on the current strategies and research advancements in enamel regeneration and dentin desensitization,and challenges of clinical translation.We emphasize that scientific research should start with clinical needs,and these studies,through translation,ultimately serve the clinic to form a mutually reinforcing virtuous cycle.This review aims to provide a new perspective on the prevention and treatment of dental hard tissues,promote innovation in restorative materials and techniques,and bring better clinical translation products and services to patients.牙齿硬组织,主要是牙釉质和牙本质,具有切割、咀嚼、说话和维持面部美观等基本功能,主要由排列良好的羟基磷灰石纳米晶体与蛋白质基质交错组成.这些组织表现出非凡的机械和美学行为,然而,一旦受损,它的自我修复能力是极其有限的,常伴有牙本质过敏.目前,虽然利用合成材料和再矿化技术进行牙体修复取得了临床进展,但这些方法仍然存在局限性,影响了其在临床中的广泛应用.因此,了解牙齿硬组织的形成机制,开发出能够模拟天然牙齿并满足临床需要的高性能再生技术是至关重要的.本文就牙釉质再生和牙本质脱敏的研究现状、研究进展以及临床转化面临的挑战进行综述.我们强调科学研究应以临床需求为出发点,这些研究通过转化最终服务于临床形成一种互相促进的良性循环.本文旨在为牙齿硬组织的预防和治疗提供新的视角,促进修复材料和技术的创新,为患者提供更好的临床转化产品和服务.

关 键 词：pits and fissures ENAMEL dentin hypersensitivity clinical translation 

分 类 号：R783.1[医药卫生—口腔医学]