肾细胞癌脑转移患者预后分析  

Prognosis Analysis of Patients with Brain Metastasis of Renal Cell Carcinoma

作　　者：王利利 李文良 WANG Lili;LI Wenliang(Department of Radiotherapy,Tianjin Hospital,Tianjin 300211,China;Department of Brain Oncology,Tianjin Cancer Hospital,Tianjin 300211,China)

机构地区：[1]天津市天津医院放疗科,天津300211 [2]天津医科大学肿瘤医院脑系肿瘤科,天津300211

出　　处：《中国药物滥用防治杂志》2024年第11期2038-2040,共3页Chinese Journal of Drug Abuse Prevention and Treatment

基　　金：国家自然科学基金青年项目(编号:82272639)。

摘　　要：目的:回顾性分析探肾细胞癌脑转移患者生存预后相关因素。方法:收集2007年1月—2019年6月入院诊断为肾癌脑转移患者42例,通过K-M单因素生存分析及COX多因素回归分析影响肾癌脑转移患者预后相关因素。结果:纳入42例患者,中位总生存期为13.233个月,总生存时间为1.30~133.80个月。采用K-M单因素及COX回归多因素分析显示,患者KPS评分(OR:0.431,95%CI:0.213~0.873,P=0.019)、脑转移数目(OR:3.267,95%CI:1.832~5.585,P<0.001)及SRS(OR:0.198,95%CI:0.091~0.430,P<0.001)为影响患者生存预后的独立预后因素。结论:KPS评分、脑转移数目、SRT为影响患者生存预后的重要因素。Objective:To retrospectively analyze the related factors of survival and prognosis in patients with brain metastasis of renal cell carcinoma.Methods:From January 2007 to June 2019,42 patients with brain metastasis of renal cell carcinoma were collected.The prognostic factors of patients with brain metastasis of renal cell carcinoma were analyzed by K-M univariate survival analysis and COX multivariate regression analysis.Results:A total of 42 patients were included,the median overall survival time was 13.233 months,and the overall survival time was 1.30~133.80 months.K-M univariate and COX regression multivariate analysis showed that KPS score(OR:0.431,95%CI:0.213~0.873,P=0.019),number of brain metastases(OR:3.267,95%CI:1.832~5.585,P<0.001)and SRS(OR:0.198,95%CI:0.091~0.430,P<0.001)were independent prognostic factors affecting the survival and prognosis of patients..Conclusion:KPS score,number of brain metastases and SRT are important factors affecting the survival and prognosis of patients.

关 键 词：肾细胞癌 脑转移 预后 SRS 

分 类 号：R737.11[医药卫生—肿瘤]