己酮可可碱对脑梗死合并老年衰弱综合征患者神经和认知功能障碍的影响  

Effect of pentoxifylline on neurological and cognitive dysfunction in elderly patients with cerebral infarction-related frailty

作　　者：李净兵 王会军[2] 王少颖 赵璨 王莉迪 曹玉娇 LI Jingbing;WANG Huijun;WANG Shaoying;ZHAO Can;WANG Lidi;CAO Yujiao(Department of Neurology,Eighth People's Hospital of Hebei Province,Shijiazhuang 05001l,China;Department of Neurology,First Hospital of Baoding City,Baoding 071000,China;Department of Cardiology,Eighth People's Hospital of Hebei Province,Shijiazhuang 05001l,China)

机构地区：[1]河北省第八人民医院神经内科,石家庄050011 [2]河北省保定市第一医院神经内科,保定071000 [3]河北省第八人民医院心内科,石家庄050011

出　　处：《中国临床药学杂志》2024年第10期765-769,共5页Chinese Journal of Clinical Pharmacy

基　　金：河北省医学科学研究课题计划项目(编号20200703)。

摘　　要：目的探讨己酮可可碱对脑梗死合并老年衰弱综合征患者神经和认知功能障碍的改善作用。方法选择2020年1月至2022年1月我院收治的脑梗死合并老年衰弱综合征患者160例,采用随机数字表法分为对照组(80例,采用常规基础治疗)与研究组(80例,在对照组治疗基础上加用己酮可可碱)。采集患者的临床资料,比较2组患者神经和认知功能障碍的改善效果及不良反应发生率。结果治疗前,2组患者的神经功能缺损程度(NIHSS)评分、日常生活活动(ADL)评分、局部脑血流(rCBF)评分、简易精神状态检查量表(MMSE)评分和蒙特利尔认知评测量表(MoCA)评分比较差异均无统计学意义(均P>0.05);治疗后,2组患者的NIHSS评分均较治疗前显著降低(P<0.05),ADL评分、rCBF评分、MMSE评分及MoCA评分均较治疗前显著升高(均P<0.05),且研究组上述指标改变程度大于对照组(均P<0.05)。2组不良反应总发生率之间差异无统计学意义(P>0.05)。结论己酮可可碱治疗脑梗死合并老年衰弱综合征的效果确切,可明显改善患者的神经和认知功能障碍,安全性好,值得推广。AIM To explore the effect of pentoxifylline on improving neurological and cognitive dysfunction in elderly patients with cerebral infarction-related frailty.METHODS A total of 160 elderly patients with cerebral infarction-related frailty admitted to our hospital from January 2020 to January 2022 were randomly divided into control group(80 patients,using conventional basic treatment)and study group(80 patients,using pentoxifylline based on conventional basic treatment).The clinical data of patients were collected.The improvement effect of neurological and cognitive dysfunction and the incidence of adverse reactions were compared between 2 groups.RESULTS Before treatment,there were no significant differences between 2 groups in the neurological function defect score(NIHSS),score of activity of daily living(ADL),regional cerebral blood flow(rCBF),mini mental status examination(MMSE)and Montreal cognitive assessment(MoCA)(all P>0.05).After treatment,the NIHSS scores of the elderly patients with frailty in 2 groups decreased obviously(P<0.05),while the ADL score,rCBF score,MMSE score,and MoCA score increased obviously(all P<0.05).Changes in the above indexes in the study group were significant(P<0.05).There was no significant difference in the total incidence of adverse reactions between 2groups(P>0.05).CONCLUSION Pentoxifylline,which has a definite effect on the treatment of elderly patients with cerebral infarction-related frailty,can significantly improve the neurological and cognitive dysfunction of patients.Moreover,it is safe and worthy of promotion.

关 键 词：脑梗死 老年衰弱综合征 己酮可可碱 神经功能 认知功能 

分 类 号：R743.33[医药卫生—神经病学与精神病学] R592[医药卫生—临床医学]