炎症性肠病相关肠纤维化发生机制研究进展  

Progress in the pathogenesis of intestinal fibrosis associated with inflammatory bowel disease

作　　者：秦弋雯 张慧敏 罗晓英 江小柯 白阳秋 张炳勇 QIN Yiwen;ZHANG Huimin;LUO Xiaoying;JIANG Xiaoke;BAI Yangqiu;ZHANG Bingyong(Department of Gastroenterology,Zhengzhou University People′s Hospital,He′nan Provincical People′s Hospital,Zhengzhou 450003,China)

机构地区：[1]郑州大学人民医院河南省人民医院消化内科,河南郑州450003

出　　处：《胃肠病学和肝病学杂志》2024年第12期1689-1692,1697,共5页Chinese Journal of Gastroenterology and Hepatology

摘　　要：肠纤维化是炎症性肠病(inflammatory bowel disease,IBD)的重要并发症。随着肠纤维化的发展,肠狭窄、肠梗阻等并发症可随之出现。目前尚无特异性抗纤维化药物来阻止其进展,仅依靠内镜下球囊扩张术、外科狭窄成形术、肠切除等方法来缓解症状。阐明肠纤维化的发生机制,有助于探索IBD相关肠纤维化治疗措施。Intestinal fibrosis is an important complication of inflammatory bowel disease(IBD).With the development of intestinal fibrosis,complications such as intestinal stenosis and intestinal obstruction may occur.At present,there are no specific antifibrotic drugs to stop the progression of fibrosis,and only endoscopic balloon dilation,surgical strictureplasty,and enterectomy are used to relieve symptoms.Elucidating the pathogenesis of intestinal fibrosis is helpful to explore the treatment measures of IBD-related intestinal fibrosis.

关 键 词：炎症性肠病 肠纤维化 上皮-间质转化 

分 类 号：R574.62[医药卫生—消化系统]