肠白塞病发病机制研究进展  

Advancements in the research of the pathogenic mechanisms of intestinal Beh et′s disease

作　　者：杨青林 万俊辰 张妙心 周琦[1] YANG Qinglin;WAN Junchen;ZHANG Miaoxin;ZHOU Qi(Department of Gastroenterology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China)

机构地区：[1]华中科技大学同济医学院附属同济医院消化内科,湖北武汉430030

出　　处：《胃肠病学和肝病学杂志》2024年第12期1698-1702,1710,共6页Chinese Journal of Gastroenterology and Hepatology

摘　　要：白塞综合征(Behcet’s syndrome,BS)是一种慢性、周期性复发的全身性血管炎疾病,其典型临床表现为反复发作的口腔与生殖器溃疡。其中,肠白塞病作为BS的一种亚型,主要以肠溃疡为临床特征。肠白塞病的临床表现多样,可能并发严重病症,从而增加死亡风险,加重经济负担,且显著降低患者的生活品质。虽然肠白塞病的发病机理尚未彻底明了,但现有研究揭示其可能与遗传素质、环境因素、免疫调节失衡及肠道微生物群的变化密切相关。对这些病因的深入理解对于提高早期诊断精准度和开发更有效治疗手段具有重大意义。当前,关于BS的病理生理学的研究已较为充分,然而,针对肠白塞病亚型的研究文献相对较少。本文将侧重对肠白塞病涉及的遗传背景、免疫机制、环境因素和肠道微生态失衡等方面的研究进展进行综述。Behcet′s syndrome(BS)is a chronic,relapsing systemic vasculitis characterized by recurrent oral and genital ulcers.Intestinal Beh et′s disease,a subtype of BS,is primarily marked by intestinal ulcerations.The clinical presentation of intestinal Behcet′s disease can be diverse and may be complicated by severe conditions,thereby increasing mortality risk,economic burden,and significantly diminishing patients′quality of life.Although the pathogenesis of intestinal Behcet′s disease is not fully understood,current research suggests a close association with genetic predispositions,environmental factors,dysregulation of immune responses,and alterations in the gut microbiome.A deeper understanding of these etiological factors is crucial for enhancing early diagnostic accuracy and developing more effective therapeutic interventions.While pathophysiological studies on BS are well-established,there is a relative paucity of literature specifically addressing the intestinal Beh et′s disease subtype.This article provided a comprehensive review of the advances in research concerning the genetic background,immunological mechanisms,environmental influences,and dysbiosis of the gut microbiota associated with intestinal Behcet′s disease.

关 键 词：白塞综合征 肠白塞病 发病机制 肠道微生态 

分 类 号：R574[医药卫生—消化系统]