Biosafety and immunology:An interdisciplinary field for health priority  

作　　者：Jun Liu Gary Wong Hui Li Yan Yang Yuxi Cao Yongfeng Li Yan Wu Zijie Zhang Cong Jin Xi Wang Yongwen Chen Bin Su Zhongfang Wang Qihui Wang Yunlong Cao Guobing Chen Zhaohui Qian Jincun Zhao Guizhen Wu 

机构地区：[1]NHC Key Laboratory of Biosafety,National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases(NITFID),Research Unit of Adaptive Evolution and Control of Emerging Viruses,Chinese Academy of Medical Sciences,National Institute for Viral Disease Control and Prevention,Chinese Center for Disease Control and Prevention,Beijing 102206,China [2]Virology Unit,Institut Pasteur du Cambodge,Pasteur Network,Phnom Penh 12000,Cambodia [3]Department of Pulmonary and Critical Care Medicine,Center for Respiratory Diseases,China-Japan Friendship Hospital,Beijing 100029,China [4]State Key Laboratory for Animal Disease Control and Prevention,Harbin Veterinary Research Institute,Chinese Academy of Agricultural Sciences,Harbin 150040,China [5]Laboratory of Pathogenic Microbiology and Immunology,Institute of Microbiology,Chinese Academy of Sciences,and School of Basic Medical Sciences,Capital Medical University,Beijing 100069,China [6]State Key Laboratory for Conservation and Utilization of Bio-resource and School of Life Sciences,Yunnan University,Kunming 650091,China [7]National Center for AIDS/STD Control and Prevention,Chinese Center for Disease Control and Prevention,Beijing 102206,China [8]Department of Immunology,School of Basic Medical Sciences,Capital Medical University,Beijing 100069,China [9]Institute of Immunology,PLA,Third Military Medical University,Chongqing 200025,China [10]Beijing Key Laboratory for HIV/AIDS Research,Beijing Youan Hospital,Capital Medical University,Beijing 100069,China [11]Guangzhou Laboratory,Guangzhou 510005,China [12]CAS Key Laboratory of Pathogen Microbiology and Immunology,Institute of Microbiology,Chinese Academy of Sciences,Beijing 100101,China [13]Changping Laboratory,Beijing 102200,China [14]Key Laboratory of Viral Pathogenesis&Infection Prevention and Control(Jinan University),Ministry of Education,Department of Microbiology and Immunology,Institute of Geriatric Immunology,School of Medicine,Jinan University,Guangzhou 510632,China [15]NHC Key Laboratory of System

出　　处：《Biosafety and Health》2024年第5期310-318,共9页生物安全与健康（英文）

基　　金：supported by the National Key R&D Program of China(2022YFC2604100);the National Natural Science Foundation of China(82241072).

摘　　要：Biosafety hazards can trigger a host immune response after infection,invasion,or contact with the host.Whether infection with a microorganism results in disease or biosafety concerns depends to a large extent on the immune status of the population.Therefore,it is essential to investigate the immunological character-istics of the host and the mechanisms of biological threats and agents to protect the host more effectively.Emerging and re-emerging infectious diseases,such as the current coronavirus disease 2019(COVID-19)pan-demic,have raised concerns regarding both biosafety and immunology worldwide.Interdisciplinary studies involved in biosafety and immunology are relevant in many fields,including the development of vaccines and other immune interventions such as monoclonal antibodies and T-cells,herd immunity(or population-level barrier immunity),immunopathology,and multispecies immunity,i.e.,animals and even plants.Meanwhile,advances in immunological science and technology are occurring rapidly,resulting in important research achievements that may contribute to the recognition of emerging biosafety hazards,as well as early warning,prevention,and defense systems.This review provides an overview of the interdisciplinary field of biosafety and immunology.Close collaboration and innovative application of immunology in the field of bio-safety is becoming essential for human health.

关 键 词：IMMUNOLOGY BIOSAFETY Diagnosis PROPHYLAXIS THERAPY 

分 类 号：R749.1[医药卫生—神经病学与精神病学]