MITF在疾病发生中作用的研究进展  

Research Progress on the Roles of MITF in Disease Pathogenesis

作　　者：覃书瀛 张淑静 庞秋香[1] QIN Shuying;ZHANG Shujing;PANG Qiuxiang(School of Life Sciences and Medicine,Shandong University of Technology,Zibo 255000,China)

机构地区：[1]山东理工大学生命与医药学院,淄博255000

出　　处：《中国细胞生物学学报》2024年第11期1954-1960,共7页Chinese Journal of Cell Biology

基　　金：国家自然科学基金(批准号:32302975);山东省自然科学基金(批准号:ZR2023QC068)资助的课题。

摘　　要：小眼畸形相关转录因子(microphthalmia-associated transcription factor,MITF)属于碱性螺旋–环–螺旋亮氨酸拉链(basic helix-loop-helix leucine zipper,bHLH-LZ)家族,广泛存在于各类动物包括无脊椎动物中,其主要功能为调节黑色素的生成。多项研究显示MITF在不同组织器官和环境中存在十余种不同亚型,通过调控众多靶基因的表达参与细胞存活、增殖、分化、代谢、DNA损伤修复等生物过程。随着研究的进行,目前已发现MITF与多种疾病密切相关。该文主要对MITF的生物学功能及其与各类疾病发生的相关性进行了综述,以期为进一步的疾病机制研究提供参考,为相关疾病治疗提供新的思路。MITF(microphthalmia-associated transcription factor)is a member of the bHLH-LZ(basic helix-loop-helix leucine zipper)family,widely presents across various animals,including invertebrates,primarily regulating melanin production.Recent researches show that over ten distinct subtypes of MITF have been identified across different tissues,organs,and environments.MITF contributes to biological processes including cell survival,proliferation,differentiation,metabolism,and DNA damage repair by modulating the expression of numerous target genes.With the progress of research,it has been discovered that MITF is closely linked to numerous diseases.This review primarily explores the biological functions of MITF and its relevance in the pathogenesis of various diseases,aiming to inform further mechanistic studies and suggest novel therapeutic approaches for related diseases.

关 键 词：小眼畸形相关转录因子 黑色素 靶基因 疾病发生 

分 类 号：R363[医药卫生—病理学]