基于微环境调控的多发性硬化症髓鞘再生策略  

Myelin Regeneration Strategy for Multiple Sclerosis Based on Microenvironment Regulation

作　　者：金书棋 罗富成 崔健臣 JIN Shuqi;LUO Fucheng;CUI Jianchen(State Key Laboratory of Primate Biomedical Research,Institute of Primate Translational Medicine,Kunming University of Science and Technology,Kunming 650500,China;Department of Anesthesiology,First People’s Hospital of Yunnan Province,Kunming 650032,China;Department of Anesthesiology,Affiliated Hospital of Kunming University of Science and Technology,Kunming 650032,China)

机构地区：[1]昆明理工大学灵长类转化医学研究院,省部共建非人灵长类生物医学国家重点实验室,昆明650500 [2]云南省第一人民医院麻醉科,昆明650032 [3]昆明理工大学附属医院麻醉科,昆明650032

出　　处：《中国细胞生物学学报》2024年第11期1968-1975,共8页Chinese Journal of Cell Biology

基　　金：云南省基础研究计划(批准号:202401AT070023);中国博士后科学基金(批准号:2023MD734240);昆明理工大学医学联合专项(批准号:KUSTKH2022034Y)资助的课题。

摘　　要：多发性硬化症(multiple sclerosis,MS)是一种因免疫系统攻击髓鞘而引发的炎性脱髓鞘疾病。髓鞘再生对神经功能的恢复至关重要,但在MS患者中,这一过程常被阻碍。随着对髓鞘再生的微环境影响逐渐被揭示,研究人员开始关注其在MS中的作用机制。理解并调控MS中的微环境,可能为开发新的治疗策略提供新的思路。该文总结了髓鞘再生的微环境调控研究进展,探讨了不同微环境因子如何影响髓鞘再生及其对未来MS治疗的潜在意义。MS(multiple sclerosis)is an inflammatory demyelinating disease caused by the immune system attacking the myelin sheath.Myelin regeneration is crucial for the recovery of nerve function,but in MS patients,this process is often hindered.As the influence of the microenvironment on myelin regeneration is gradually revealed,researchers begin to pay attention to its mechanism of action in MS.Understanding and regulating the microenvironment in MS may provide new ideas for developing new treatment strategies.This article summarizes the research progress in the microenvironment regulation of myelin regeneration and discusses how different microenvironmental factors affect myelin regeneration and its potential significance for future MS treatment.

关 键 词：多发性硬化症 微环境 少突胶质细胞 髓鞘再生 

分 类 号：R744.51[医药卫生—神经病学与精神病学]