透明病理--核医学分子影像在肿瘤表型中的实践  

Transpathology-practice of nuclear medicine and molecular imaging in cancer phenotyping

作　　者：钟燕 岑沛立[1,2,3] 周金云 金晨涛 姚琼 王菁[1,2,3] 田梅[5] 张宏[1,2,3,4] Zhong Yan;Cen Peili;Zhou Jinyun;Jin Chentao;Yao Qiong;Wang Jing;Tian Mei;ZhangHong(Department of Nuclear Medicine,the Second Affiliated Hospital of Zhejiang University School of Medicine,Hangzhou 310009,China;Zhejiang University Medical PET Center,Hangzhou 310009,China;Key Laboratory of Medical Molecular Imaging of Zhejiang Province,Hangzhou 310009,China;Key Laboratory for Biomedical Engineering of Ministry of Education,Zhejiang University,Hangzhou 310027,China;Human Phenome Institute,Fudan University,Shanghai 201203,China)

机构地区：[1]浙江大学医学院附属第二医院核医学科,浙江杭州310009 [2]浙江大学医学PET中心,浙江杭州310009 [3]浙江省医学分子影像重点实验室,浙江杭州310009 [4]浙江大学生物医学工程教育部重点实验室,浙江杭州310027 [5]复旦大学人类表型组研究院,上海201203

出　　处：《实用肿瘤杂志》2024年第6期506-514,共9页Journal of Practical Oncology

基　　金：国家自然科学基金重点项目(82030049);国家重大科研仪器研制项目(32027802);国家重点研发计划项目(2021YFA1101700);国家自然科学基金国际合作重点项目A3前瞻计划项目(82361148130);国家自然科学基金重大项目(82394430,82394433);中央高校基本科研业务专项资金资助(226-2024-00059)。

摘　　要：过去几十年的肿瘤生物学研究深入解析了肿瘤细胞的生物学特征,并识别出肿瘤在发生过程中的各种生物特征。然而,有效地将这些肿瘤的生物特征进行成像以辅助患者的临床管理仍具有挑战性。核医学分子影像领域的快速发展为探究肿瘤的体内生物学特征提供了机遇。本文梳理了核医学分子影像技术在表征肿瘤生物特征方面的现状,并探讨了体表型策略的核医学分子影像在肿瘤中的未来研究方向。During the past several decades,numerous studies have provided insights into the biological characteristics of cancer cells,and identified various hallmarks of cancer during the tumorigenic processes.However,it remains challenging to image these distinctive traits of cancer to facilitate patient management in clinical settings.The rapid development of nuclear medicine and molecular imaging has provided opportunities to investigate the in vivo biological characteristics of cancer.This article reviews the current status of nuclear medicine and molecular imaging on characterizing the hallmarks of cancer,and discusses the future directions of nuclear medicine and molecular imaging strategies to promote cancer phenotyping in vivo.

关 键 词：肿瘤 生物标志物 正电子发射断层显像 核医学分子影像 

分 类 号：R730.44[医药卫生—肿瘤]