肿瘤影像学:临床应用现状、进展及挑战  

Cancer imaging:clinical application,achievements and challenges

作　　者：张晓辉 罗晓芸[1,2] 肖美玲 姚琼 王菁[1,2,3] 田梅[4] 张宏[1,2,3,5] Zhang Xiaohui;Luo Xiaoyun;Xiao Meiling;Yao Qiong;Wang Jing;Tian Mei;Zhang Hong(Department of Nuclear Medicine,the Second Affiliated Hospital of Zhejiang University School of Medicine,Hangzhou 310009,China;Zhejiang University Medical PET Center,Hangzhou 310009,China;Key Laboratory of Medical Molecular Imaging of Zhejiang Province,Hangzhou 310009,China;Human Phenome Institute,Fudan University,Shanghai 201203,China;Key Laboratory for Biomedical Engi neering of Ministry of Education,Zhejiang University,Hangzhou 310027,China)

机构地区：[1]浙江大学医学院附属第二医院核医学科,浙江杭州310009 [2]浙江大学医学PET中心,浙江杭州310009 [3]浙江省医学分子影像重点实验室,浙江杭州310009 [4]复旦大学人类表型组研究院,上海201203 [5]浙江大学生物医学工程教育部重点实验室,浙江杭州310027

出　　处：《实用肿瘤杂志》2024年第6期514-520,共7页Journal of Practical Oncology

基　　金：国家自然科学基金重点项目(82030049);国家重大科研仪器研制项目(32027802);国家重点研发计划项目(2021YFA1101700);国家自然科学基金国际合作重点项目A3前瞻计划项目(82361148130);国家自然科学基金重大项目(82394430,82394433)。

摘　　要：恶性肿瘤是全球范围内威胁人类生命健康的重大公共卫生问题。早期、精确诊断是精准医学时代提高肿瘤治愈率和改善预后的关键。光学、X线、CT、MRI、超声和核医学等不同影像模态可从微观-介观-宏观水平表征肿瘤功能、代谢和解剖等信息变化,在肿瘤早期检测、诊断分期、疗效监测和预后评估中具有不可或缺的地位。本文阐述了不同影像方法在肿瘤诊疗中的临床应用进展,并探讨了肿瘤影像学在设备发展、影像探针/对比剂研发和临床转化等方面面临的挑战。Cancer represent a significant global public health concern,posing a substantial threat to human life and health.The enhancement of cancer survival rates and prognostic outcomes hinges on the early and precise diagnosis,particularly in the contemporary epoch of precision medicine.Various imaging modalities,such as optical imaging,X-ray,CT,MRI,ultrasound,and nuclear medicine,possess the capability to delineate alterations in tumor function,metabolism,and anatomy across microscopic,mesoscopic,and macroscopic scales.These modalities occupy a crucial role in the initial detection,diagnostic staging,monitoring of treatment,and prognostic evaluation of tumors.Despite their significance,numerous challenges persist in the realms of equipment advancement,the research and development of imaging probes/contrast agents,and clinical translation.

关 键 词：肿瘤 X线 体层摄影术 磁共振成像 正电子发射断层显像 

分 类 号：R730.4[医药卫生—肿瘤]