2011—2020年福建省肿瘤登记地区上消化道癌流行特征及生存分析  

Epidemic Characteristics and Survival Trends of Upper Gastrointestinal Cancer in Fujian Cancer Registration Areas from 2011 to 2020

作　　者：黄永迎 相智声 马晶昱 林永添[1] 温烨莹 周衍[1] HUANG Yongying;XIANG Zhisheng;MA Jingyu;LIN Yongtian;WEN Yeying;ZHOU Yan(Clinical Oncology SchoolofFujian Medical University,Fujian Cancer Hospital,Fuzhou 350014,China)

机构地区：[1]福建医科大学肿瘤临床医学院,福建省肿瘤医院,福建福州350014

出　　处：《中国肿瘤》2024年第11期886-893,共8页China Cancer

基　　金：福建省自然科学基金项目(2023J011292);福建省引导性科技计划项目(2022Y0055);福建省肿瘤医院人才引进项目(2021YNY06)。

摘　　要：[目的]分析福建省肿瘤登记地区2011—2020年上消化道癌流行特征、变化趋势和生存情况。[方法]整理分析福建省肿瘤登记数据,计算2011—2020年上消化道癌(包括食管癌和胃癌)发病和死亡粗率、中标率、世标率、累积率,采用Joinpoint线性回归模型分析上消化道癌发病和死亡的变化趋势,计算年度变化百分比(annual percentage change,APC)及平均年度变化百分比(average annual percentage change,AAPC)。将诊断时间分成2011—2015年和2016—2020年两个时间段比较上消化道癌的5年相对生存率。[结果]2011—2020年,福建省肿瘤登记地区上消化道癌新发病例26286例,占全部恶性肿瘤的20.28%,粗发病率为56.52/10万,中标率为42.55/10万,世标率为42.75/10万,0~74岁的累积发病率为5.32%,男性上消化道癌发病率高于女性。上消化道癌发病率整体呈下降趋势,中标率的AAPC为-4.7%(95%CI:-6.6%~-2.9%)。其中食管癌新发病例11680例,粗发病率、中标率、世标率和0~74岁的累积率分别为25.12/10万、18.67/10万、18.97/10万和2.32%;胃癌新发病例14606例,粗发病率、中标率、世标率和0~74岁的累积率分别为31.41/10万、23.88/10万、23.78/10万和3.00%。2011—2020年,福建省肿瘤登记地区上消化道癌死亡病例20133例,占全部恶性肿瘤死亡病例的26.05%,上消化道癌粗死亡率为43.29/10万,中标率为31.95/10万,世标率为31.89/10万,0~74岁的累积死亡率为3.84%,男性上消化道癌死亡率高于女性。上消化道癌死亡率呈现先上升后下降的趋势,2011—2014年的中标率APC为3.5%(95%CI:-0.5%~11.3%),2014—2020年为-5.2%(95%CI:-8.4%~-3.7%)。其中食管癌死亡病例9643例,粗死亡率、中标率、世标率和0~74岁累积率分别为20.74/10万、15.20/10万、15.35/10万和1.83%;胃癌死亡病例10490例,粗死亡率、中标率、世标率和0~74岁累积率分别为22.56/10万、16.75/10万、16.54/10万和2.00%。2011—2015年上消化道癌患者5年相对[Purpose]To analyze the epidemic characteristics and survival trends of upper gastrointestinal cancer in Fujian cancer registration areas from 2011 to 2020.[Methods]Cancer registration data in Fujian Province was collected to calculate the crude incidence and mortality rate,age-standardized incidence/mortality rates by Chinese standard population(ASIRC,ASMRC)and by world standard population(ASIRW,ASMRW)and cumulative rate of 0~74 years old of upper gastrointestinal cancer(including esophageal and gastric cancers)as well as the corresponding temporal trends from 2011 to 2020.Using the Joinpoint software to calculate the annual percentage change(APC)and average annual percentage change(AAPC)to analyze the trends.The data were divided into two time periods(2011—2015 and 2016—2020)to compare the 5-year relative survival rates of upper gastrointestinal cancer.[Results]From 2011 to 2020,there were 26286 new cases of upper gastrointestinal cancer in Fujian cancer registration areas,accounting for 20.28%of all malignant tumors.The incidence rate,ASIRC and ASIRW of upper gastrointestinal cancer was 56.52/105,42.55/105,and 42.75/105,respectively,and the cumulative incidence rate(0~74years old)was 5.32%.Incidence of upper gastrointestinal cancer was higher in men than that in women.The incidence of upper gastrointestinal cancer showed an decreasing trend from 2011 to 2020,with an AAPC of ASIRC of-4.7%(95%CI:-6.6%~-2.9%).There were 11680 new cases of esophageal cancer in Fujian cancer registration areas,the crude incidence,ASIRC,ASIRW and cumulative incidence(0~74 years old)of esophageal cancer were 25.12/105,18.67/105,18.97/105,and 2.32%,respectively.There were 14606 gastric cancer new cases in Fujian cancer registration areas during 2011—2020,the crude mortality,ASMRC,ASIRW and cumulative mortality(0~74years old)of gastric cancer were 31.41/105,23.88/105,23.78/105,and 3.00%,respectively.There were 20133 upper gastrointestinal cancer deaths during 2011—2020 in Fujian cancer registration areas,accounting for 26.05%of

关 键 词：上消化道癌 食管癌 胃癌 发病率 死亡率 生存率 福建 

分 类 号：R73-31[医药卫生—肿瘤] R735[医药卫生—临床医学]