代谢组学技术在肝癌病因学研究中的应用与进展  

Application and Progress of Metabolomics in the Etiology of Liver Cancer

作　　者：李卓颖 项永兵[2,3] LI Zhuoying;XIANG Yongbing(School of Public Health,Fudan University,Shanghai 200032,China;State Key Laboratory of System Medicine for Cancer,Shanghai Cancer Institute,Renji Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200032,China;Department of Epidemiology,Shanghai Cancer Institute,Shanghai 200032,China)

机构地区：[1]复旦大学公共卫生学院,上海200032 [2]上海交通大学医学院附属仁济医院肿瘤系统医学全国重点实验室,上海200032 [3]上海市肿瘤研究所流行病学研究室,上海200032

出　　处：《中国肿瘤》2024年第11期952-959,共8页China Cancer

基　　金：国家重点研发计划项目(2021YFC2500404,2021YFC2500405)。

摘　　要：代谢物作为生物体内化学反应的末端产物,是基因表达、蛋白质功能以及环境因素相互作用的最直接产物,能够综合反映生物体对内在遗传变异和外部环境变化的响应。代谢组学通过系统分析人体代谢物谱的改变,有助于发现潜在的生物标志物,为疾病的早期诊断、预防及个体化治疗提供新的思路。近年来,代谢组学技术在肝癌的病因研究中逐渐得到应用。全文对现有研究报道进行综述,以了解代谢组学技术在肝癌病因学研究中的应用,重点关注证据级别较高的前瞻性队列研究以及在队列基础上开展的巢式病例-对照研究等,归纳总结现有研究证据,为推动肝癌的病因学机制研究,了解已知危险因素的致病机制以及肝癌的风险预测提供重要的参考依据。Metabolites,as the end products of biochemical reactions within organisms,directly reflect the interplay of gene expression,protein function,and environmental factors,offering a comprehensive reflection of the organism's response to inherent genetic variations and external environmental changes.By systematically analyzing changes in human metabolite profiles,metabolomics aids in the identification of potential biomarkers,offering new insights for the early diagnosis,prevention,and personalized treatment of diseases.In recent years,research methodologies in metabolomics have increasingly been applied to the etiological studies of liver cancer.This paper aims to review existing research reports to understand the application of metabolomics in the study of liver cancer etiology,with a focus on high-level evidence from prospective cohort studies and case-control studies nested within cohorts.By summarizing the current research evidence,the paper aims to advance the study of the etiological mechanisms of liver cancer,understand the pathogenic mechanisms of known risk factors,and offer a scientific foundation for the prediction of liver cancer.

关 键 词：代谢组学 肝癌 队列研究 巢式病例-对照研究 危险因素 

分 类 号：R735.7[医药卫生—肿瘤] R181[医药卫生—临床医学]