成人局灶性癫痫发作患者临床与动态脑电图特征  

Clinical and ambulatory EEG characteristics in adult patients with focal seizures

作　　者：项郑[1] 张若怡 Xiang Zheng;Zhang Ruoyi(Department of Functional Examination,Jiangsu Province Hospital of Traditional Chinese Medicine,Nanjing City,Jiangsu Province,210000,China;Department of Neurology,Nantong Hospital of Traditional Chinese Medicine,Nantong City,Jiangsu Province,226000,China)

机构地区：[1]江苏省中医院功能检查科,江苏省南京市210000 [2]南通市中医院神经内科,江苏省南通市226000

出　　处：《现代电生理学杂志》2024年第4期195-200,共6页Journal of Modern Electrophysiology

基　　金：2018年度南通市市级科技计划项目(MSZ18265)。

摘　　要：目的探讨成人局灶性癫痫发作(FS)患者临床与动态脑电图特征。方法选取2019年1月至2024年1月江苏省中医院、合肥康安癫痫病研究所附属中医院门诊及住院收治的200例成人FS患者作为研究对象,进行24小时动态脑电图检查。分析其临床和脑电图特征。结果患者主要分布在50~69岁(65.0%)。200例FS患者病因分类:结构性128例,感染性27例,代谢性15例,免疫性11例,病因不明19例。合并脑卒中87例(43.5%),颅脑外伤史25例(12.5%)。99例(49.5%)合并焦虑,82例(41.0%)合并抑郁,合并焦虑抑郁者51例(25.5%)。脑电图表现出特异性发作波的有132例,其中仅睡眠时段出现发作波的患者32例(16.0%,32/200例),仅清醒时段出现发作波的患者46例(23.0%,46/200例),清醒及睡眠时段均有发作波患者54例(27.0%,54/200例)。各时段痫样放电出现率比较,差异具有统计学意义(P<0.01)。结论成人局灶性癫痫发作患者主要分布在50~69岁,常合并焦虑和抑郁,动态脑电图异常检出率高,通过动态脑电图异常特征,能辅助判断癫痫发作类型,从而为患者提供更加个性化和精准的治疗方案。Objective To investigate the clinical and ambulatory EEG characteristics of adult patients with focal seizure(FS).Methods Two hundred adult patients with FS admitted to Jiangsu Province Hospital of Traditional Chinese Medicine and Hefei Kang'an Epilepsy Institute Affiliated Hospital of Traditional Chinese Medicine from January 2019 to January 2024 were selected as the research subjects.All patients underwent 24-hour ambulatory EEG examination.Their clinical and EEG characteristics were analyzed.Results The patients were mainly distributed between the ages of 50 and 69(65.0%).The etiological classification of 200 patients with FS was as follows:structural 128 cases,infectious 27 cases,metabolic 15 cases,immune 11 cases,and unknown etiology 19 cases.There were 87 cases(43.5%)complicated with stroke and 25 cases(12.5%)with history of craniocerebral trauma.99 patients(49.5%)had anxiety,82 patients(41.0%)had depression,and 51 patients(25.5%)had anxiety and depression.EEG showed specific seizure waves in 132 cases,of which 32 patients(16.0%,32/200 cases)had seizure waves only during sleep,46 patients(23.0%,46/200 cases)had seizure waves only during awake,and 54 patients(27.0%,54/200 cases)had seizure waves both during awake and sleep.There was statistical significance in the occurrence rate of epileptic discharge in different periods(P<0.01).Conclusion Adults patients with FS are mainly distributed in the age range of 50-69 years old,often complicated with anxiety and depression,and the detection rate of ambulatory EEG abnormalities is high.The abnormal characteristics of ambulatory EEG can assist in judging the type of epileptic seizure,so as to provide more personalized and accurate treatment for patients.

关 键 词：癫痫 部分性 脑电描记术 成人 

分 类 号：R742.1[医药卫生—神经病学与精神病学] R741.044[医药卫生—临床医学]