肠道菌群-PPARs轴在炎症性肠病中的作用  

The role of PPARs gut microbiota axis in inflammatory bowel disease

作　　者：李建洪 徐婧 徐豪明 黄琛 聂玉强 周有连 LI Jianhong;XU Jing;XU Haoming;HUANG Chen;NIE Yuqiang;ZHOU Youlian(Department of Gastroenterology and Hepatology,the Second Affiliated Hospital,School of Medicine,South China University of Technology(Guangzhou First People’s hospital),Guangzhou 510180,China)

机构地区：[1]华南理工大学医学院第二附属医院(广州市第一人民医院)消化内科,广东广州510180

出　　处：《广州医药》2024年第11期1246-1254,共9页Guangzhou Medical Journal

基　　金：国家自然科学基金(82370552);广东省自然科学基金(2023A1515030214);广州市青年科技托举人才(QT-2023-033)。

摘　　要：炎症性肠病(IBD)作为一种慢性、易复发的炎症性疾病,被世界卫生组织归类为现代医疗领域的难治性疾病之一。其确切发病机制尚不清晰,目前主要认为与肠菌失衡触发宿主过度的肠黏膜免疫反应,进而在遗传易感性的个体中引发肠黏膜的损伤有关。目前,尚无特效的靶点能治愈IBD。过氧化物酶体增殖物激活受体(PPARs)作为核受体超家族的一员,在机体的生长发育、炎症调控以及代谢过程中扮演着重要角色,且被视为治疗包括IBD在内的多种疾病的重要潜在靶点,并被认为与肠道菌群关系密切。文章旨在探讨PPARs与肠道菌群的关系在IBD中的作用,从而挖掘IBD新的潜在诊疗靶点,开发新的治疗策略,为临床上IBD的诊断和治疗提供新的思路和方法。Inflammatory bowel disease(IBD),characterized as a chronic and recurrent inflammatory condition,is classified by the World Health Organization as one of the intractable diseases in modern medicine.The precise pathogenesis of IBD remains unclear,but current research widely believes that it is closely related to dysbiosis of the gut microbiota.Imbalance in the gut flora triggers an excessive immune response in the host’s intestinal mucosa,leading to mucosal damage in genetically susceptible individuals.To date,no specific targets have been identified that can cure IBD.Peroxisome proliferator-activated receptors(PPARs),as members of the nuclear receptor superfamily,play significant roles in growth and development,inflammation regulation,and metabolic processes.They are regarded as potential effective targets for treating various diseases,including IBD,and are closely related to the gut microbiota.This review aims to discuss the progress in understanding the role of the relationship between PPARs and gut microbiota in IBD,so as to find new potential targets for the diagnosis and treatment of IBD,develop new treatment strategies,provide new ideas and methods for the diagnosis and treatment of IBD in clinical practice.

关 键 词：肠道菌群 炎症性肠病 PPARS 

分 类 号：R574[医药卫生—消化系统]