577 nm激光微脉冲模式、532 nm激光光凝治疗中心性浆液性脉络膜视网膜病变患者的疗效比较  

Comparison of 577 nm Laser Micropulse Mode and 532 nm Laser Photocoagulation in the Treatment of Patients with Central Serous Chorioretinopathy

作　　者：彭昕 李东慧 蒋倩 王启常[1] PENG Xin;LI Donghui;JIANG Qian(Changsha Xiangjiang Aier Eye Hospital,Changsha Hunan 410000)

机构地区：[1]长沙湘江爱尔眼科医院,湖南长沙410000

出　　处：《医学临床研究》2024年第11期1640-1643,共4页Journal of Clinical Research

基　　金：湖南省临床医疗技术创新引导项目(编号:2021SK50109)。

摘　　要：【目的】比较577 nm激光微脉冲模式、532 nm激光光凝治疗中心性浆液性脉络膜视网膜病变(central serous chorioretinopathy,CSC)患者的疗效。【方法】选取2021年9月至2023年8月在本院经荧光素眼底血管造影、吲哚菁绿血管造影、光学相干断层成像检查(OCT)检查确诊的60例(60只眼)CSC患者,按照自愿原则分为观察组(接受577 nm激光微脉冲模式治疗)和对照组(接受532 nm激光光凝治疗),每组30例(30只眼)。比较两组治疗前及治疗后1个月、3个月、6个月最佳矫正视力(BCVA)、黄斑中心区视网膜厚度(central macular thickness,CMT)、黄斑中心凹下脉络膜厚度(subfovea choroidal thickness,SCT)和视网膜下液(subretinal fluid,SRF)高度。【结果】与治疗前比较,两组治疗1个月后的BCVA、CMT和SRF高度均改善(P<0.05),SCT无明显改善(P>0.05);治疗3个月后,两组SCT均下降(P<0.05)。两组治疗后1个月、3个月和6个月的BCVA、CMT和SRF高度比较,差异均无统计学意义(P>0.05);两组治疗后1个月、6个月的SCT比较,差异均无统计学意义(P>0.05);观察组治疗后3个月SCT低于对照组,差异有统计学意义(P<0.05)。两组患者治疗后1个月、3个月、6个月SRF的完全吸收率比较,差异均无统计学意义(P>0.05)。【结论】577 nm激光微脉冲模式和532 nm激光光凝治疗CSC患者1个月后均能改善视力,降低CMT和SRF高度;两种激光治疗3个月后均能降低SCT,但577 nm激光微脉冲模式降低更明显。【Objective】To compare the efficacy of 577 nm laser micropulse mode and 532 nm laser photocoagulation in the treatment of central serous chorioretinopathy(CSC).【Methods】Sixty patients(60 eyes)with CSC diagnosed by fluorescein fundus angiography,indocyanine green angiography and optical coherence tomography(OCT)were selected from September 2021 to August 2023 in our hospital.They were voluntarily divided into the observation group(receiving 577 nm laser micropulse mode treatment)and the control group(receiving 532 nm laser photocoagulation treatment),with 30 cases(30 eyes)in each group.The best corrected visual acuity(BCVA),central macular thickness(CMT)and subfovea choroidal thickness(SCT)and subretinal fluid(SRF)were compared between the two groups before treatment and at 1 month,3 months and 6 months after treatment.【Results】Compared with before treatment,the BCVA,CMT and SRF heights of both groups were improved(P<0.05)after 1 month of treatment,while SCT was not significantly improved(P>0.05).After 3 months of treatment,SCT decreased in both groups(P<0.05).There was no significant difference in BCVA,CMT and SRF height between the two groups at 1 month,3 months and 6 months after treatment(P>0.05).There was no significant difference in SCT at 1 month and 6 months after treatment between the two groups(P>0.05).The SCT of the observation group was lower than that of the control group at 3 months after treatment,and the difference was statistically significant(P<0.05).There was no significant difference in SRF absorption rate at 1 month,3 months and 6 months after treatment between the two groups(P>0.05).【Conclusion】Both 577 nm laser micropulse mode and 532 nm laser photocoagulation can improve visual acuity and reduce the height of CMT and SRF in CSC patients after 1 month.Both laser treatments reduced SCT after 3 months,but the reduction was more pronounced in the 577 nm laser micropulse mode.

关 键 词：中心性浆液性脉络膜视网膜病变 激光凝固术/方法 治疗结果 

分 类 号：R774.1[医药卫生—眼科]