奥拉西坦联合倍他司汀治疗卒中后眩晕对患者脑血流及血清AngⅡ、PDGF-BB水平的影响  

Effects of Oxiracetam Combined with Betahistine on Cerebral Blood Flow and Serum Levels of AngⅡand PDGF-BB in Patients with Post-Stroke Dizziness

作　　者：郑春利 李朋菊 ZHENG Chunli;LI Pengju(Department of Neurology,Xi'an Daxing Hospital,Xi'an Shaanxi 710016)

机构地区：[1]西安大兴医院神经内科,陕西西安710016

出　　处：《医学临床研究》2024年第11期1669-1671,1675,共4页Journal of Clinical Research

摘　　要：【目的】探讨奥拉西坦联合倍他司汀治疗卒中后眩晕对患者脑血流及血管紧张素Ⅱ(AngⅡ)、血小板衍生生长因子-BB(PDGF-BB)的影响。【方法】78例脑卒中后眩晕患者,随机分为对照组和观察组,每组39例。对照组给予甲磺酸倍他司汀片治疗,观察组在对照组基础上加用奥拉西坦治疗。比较两组患者治疗前后的脑血流量、血清AngⅡ、PDGF-BB水平,眩晕程度眩晕调查问卷(UCLA-DQ)、运动敏感度指数量表(MSQ)评分。【结果】治疗后,两组患者的脑血流量较治疗前显著提升(P<0.05),且观察组高于对照组(P<0.05);AngⅡ、PDGF-BB水平较治疗前均显著下降(P<0.05),且观察组低于对照组(P<0.05)。两组治疗后UCLA-DQ、MSQ评分均较治疗前降低(P<0.05),且观察组各项评分均低于对照组(P<0.05)。【结论】奥拉西坦联合倍他司汀能显著改善卒中后眩晕患者病灶区域的脑血量,降低血清AngⅡ、PDGF-BB水平,改善患者眩晕症状,提高生活质量,值得临床推广应用。【Objective】To investigate the effects of combined treatment of Oxiracetam with Betahistine on cerebral blood flow and levels of angiotensinⅡ(AngⅡ)and platelet-derived growth factor-BB(PDGF-BB)in patients with post-stroke dizziness.【Methods】Seventy-eight patients with post-stroke dizziness were randomly divided into the control group and the observation group,with 39 patients in each group.The control group was treated with betahistine mesylate tablets,while the observation group received additional treatment with xxiracetam in addition to betahistine.The cerebral blood flow,serum levels of AngⅡand PDGF-BB,dizziness severity(as assessed by the UCLA-DQ),and motion sensitivity(as assessed by the MSQ)were compared between the two groups before and after treatment.【Results】After treatment,both groups showed a significant increase in cerebral blood flow compared to before treatment(P<0.05),with the observation group exhibiting a greater increase than the control group(P<0.05).The levels of AngⅡand PDGF-BB significantly decreased after treatment in both groups(P<0.05),with lower levels observed in the observation group compared to the control group(P<0.05).The UCLA-DQ and MSQ scores significantly decreased after treatment in both groups(P<0.05),with the observation group showing lower scores than the control group(P<0.05).【Conclusion】The combination of oxiracetam and betahistine significantly improves cerebral blood flow in the affected regions of patients with post-stroke dizziness,reduces serum levels of AngⅡand PDGF-BB,alleviates dizziness symptoms,and enhances the quality of life.This treatment approach is worthy of clinical promotion and application.

关 键 词：卒中/并发症 眩晕/并发症 倍他司汀/治疗应用 脑血管循环 血管紧张素Ⅱ/血液 

分 类 号：R743.3[医药卫生—神经病学与精神病学]