右美托咪定与哌替啶在肝癌射频消融术患者中的麻醉效果比较  

Comparison of Anesthetic Effects of Dexmedetomidine and Pethidine in Patients Undergoing Radiofrequency Ablation for Liver Cancer

作　　者：杨煜[1] 刘岷[1] 朱芩芩[1] YANG Yu;LIU Min;ZHU Qinqin(Department of Anesthesiology,Shanghai Huangpu District Traditional Chinese and Western Medicine Hospital,Shanghai 200436)

机构地区：[1]上海市黄浦区中西医结合医院麻醉科,上海200436

出　　处：《医学临床研究》2024年第11期1689-1691,共3页Journal of Clinical Research

摘　　要：【目的】比较右美托咪定(Dex)与哌替啶在肝癌肿瘤射频消融术患者中的麻醉效果。【方法】98例择期行肿瘤射频消融术的肝癌患者,按照麻醉方法不同分为观察组(使用Dex麻醉,n=50)和对照组(使用哌替啶麻醉,n=48)。比较两组患者入室平卧10 min(T 0)、手术开始10 min(T 1)、术毕(T 2)和术后24 h(T 3)的Ramsay镇静评分、心率(HR)、平均动脉压(MAP)、脑氧饱和度(rSO 2)水平以及手术期间不良反应发生情况。【结果】T 1、T 2时,两组患者的Ramsay镇静评分均高于T 0时(P<0.05),且观察组T 1、T 2时Ramsay镇静评分均高于对照组(P<0.05);T 1时,两组患者HR、MAP均低于T 0时,两组患者T 2时rSO 2均高于T 0时(P<0.05),对照组T 2时HR、MAP均低于T 0时,T 1时rSO 2高于T 0时(P<0.05),观察组T 2时HR、MAP均高于对照组(P<0.05),rSO 2低于对照组(P<0.05)。观察组不良反应总发生率低于对照组(P<0.05)。【结论】相比哌替啶,Dex用于肝癌肿瘤射频消融术患者中的麻醉效果更好,且对rSO 2影响更小,能够降低患者不良反应发生率。【Objective】To compare the anesthetic effects of dexmedetomidine(Dex)and pethidine on patients undergoing radiofrequency ablation for liver cancer and their impact on regional cerebral oxygen saturation(rSO 2).【Methods】A total of 98 patients scheduled for radiofrequency ablation for liver cancer were divided into two groups based on the anesthetic methods:the observation group(Dex,n=50)and the control group(pethidine,n=48).The Ramsay sedation score,heart rate(HR),mean arterial pressure(MAP),rSO 2 levels,and incidence of adverse reactions were compared between the two groups at baseline(T 0),10 minutes before the start of the procedure(T 1),at the end of the procedure(T 2),and 24 hours postoperatively(T 3).【Results】At T 1 and T 2,the Ramsay sedation scores of both groups were higher than that at T 0(P<0.05),and the observation group had higher Ramsay sedation scores than the control group at T 1 and T 2(P<0.05).At T 1,both groups had lower HR and MAP compared to T 0,and at T 2,both groups had higher rSO 2 levels compared to T 0(P<0.05).The control group had lower HR and MAP at T 2 compared to T 0,and higher rSO 2 at T 1 compared to T 0(P<0.05).At T 2,the HR and MAP of the observation group were higher than those of the control group(P<0.05),while rSO 2 was lower(P<0.05).The overall incidence of adverse reactions in the observation group was lower than that in the control group(P<0.05).【Conclusion】Compared to pethidine,Dex provides better anesthetic effects for patients undergoing radiofrequency ablation for liver cancer,has a smaller impact on rSO 2,and reduces the incidence of adverse reactions.

关 键 词：肝肿瘤 导管消融术 右美托咪定/治疗应用 哌替啶/治疗应用 麻醉 

分 类 号：R735.7[医药卫生—肿瘤]