三黄解毒汤对智齿冠周炎患者冠周袋内菌群、ESR及CRP水平的影响  

Therapeutic effect of Sanhuang Jiedu Decoction on pericoronitis-induced microflora alterations,ESR,and CRP levels

作　　者：苏夏 刘海英 SU Xia;LIU Hai-ying(Guangdong Provincial People's Hospital Ganzhou Hospital/Ganzhou Municipal Hospital,Ganzhou,Jiangxi 341000;Gao'an People's Hospital,Gao'an,Jiangxi 330800)

机构地区：[1]广东省人民医院赣州医院/赣州市立医院,江西赣州341000 [2]高安市人民医院,江西高安330800

出　　处：《赣南医科大学学报》2024年第11期1137-1140,共4页JOURNAL OF GANNAN MEDICAL UNIVERSITY

摘　　要：目的:探讨智齿冠周炎患者应用三黄解毒汤治疗的效果。方法:根据治疗方案将2019年4月至2021年11月于广东省人民医院赣州医院就诊的92例急性智齿冠周炎患者分为对照组和观察组,各46例。对照组予以西医常规治疗,观察组在对照组基础上加用三黄解毒汤治疗,均连续治疗3 d。对2组临床疗效、中医证候积分、冠周袋内菌群及血沉(Erythrocyte sedimentation rate,ESR)、C反应蛋白(C-reactive protein,CRP)水平进行比较。结果:治疗后,观察组临床总有效率(97.83%)高于对照组(82.61%),中医证候积分、细菌值、革兰阴性菌比例、螺旋体比例及ESR、CRP水平低于对照组,革兰阳性菌比例高于对照组,差异均有统计学意义(P<0.05)。对照组发生恶心呕吐2例、腹泻1例、头晕1例,观察组发生恶心呕吐1例、腹泻2例,2组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:智齿冠周炎患者应用三黄解毒汤治疗可调节冠周袋内菌群,抑制炎症反应,改善患者临床症状,效果显著。Objective:To assess the therapeutic efficacy of Sanhuang Jiedu Decoction on pericoronitis.Methods:A total of 92 patients diagnosed with acute pericoronitis and treated in our hospital from April 2019 to November 2021 were enrolled in this randomized controlled trial.They were randomly divided into control group and observation group,with 46 cases in each group.The control group received routine treatment of Western medical,while the observation group was administered Sanhuang Jiedu Decoction.They were treated for three days.Outcomes assessed and compared included clinical efficacy,Traditional Chinese Medicine(TCM)syndrome score,microflora composition within the pericoronal pocket,ESR,and CRP levels.Results:After treatment,the observation group exhibited a significantly higher total clinical effective rate(97.83%)compared with that(82.61%)of the control group.The TCM syndrome score,bacterial load,prevalence of gram-negative bacteria and spirochaetae,as well as CRP and ESR levels,were all found to be lower in the observation group than those in the control group.The proportion of gram-positive bacteria was higher in the observation group.These differences were statistically significant(P<0.05).In the control group,there were 2 cases with nausea and vomiting,1 case with diarrhrea,1 case of dizziness;In the observation group,1 case with nausea and vomiting,2 cases with diarrhrea,the adverse reactions between the two groups were not statistically significant(P>0.05).Conclusion:Sanhuang Jiedu Decoction is very effective in regulating the microflora within pericoronal pockets,mitigating inflammatory responses,and ameliorating clinical symptoms associated with pericoronitis.

关 键 词：智齿冠周炎 冠周袋内菌群 三黄解毒汤 血沉 C反应蛋白 

分 类 号：R784.1[医药卫生—口腔医学]