不同新辅助化疗方案对三阴性乳腺癌患者病理完全缓解率的影响  

Effect of Different Neoadjuvant Chemotherapy Regimens on Pathological Complete Response Rate of Patients with Triple-Negative Breast Cancer

作　　者：徐骁诚 施汪添翼 XU Xiaocheng;SHI Wangtianyi(Department of Thyroid and Breast Surgery,Suzhou Ninth People's Hospital,Suzhou 215000,China;Department of Oncology,Suzhou Ninth People's Hospital,Suzhou 215000,China)

机构地区：[1]苏州市第九人民医院甲乳外科,江苏苏州215000 [2]苏州市第九人民医院肿瘤内科,江苏苏州215000

出　　处：《反射疗法与康复医学》2024年第13期119-122,126,共5页Reflexology And Rehabilitation Medicine

摘　　要：目的比较不同新辅助化疗方案对三阴性乳腺癌患者病理完全缓解率的影响。方法回顾性分析2015年1月—2021年4月于苏州市第九人民医院确诊为三阴性乳腺癌并接受新辅助化疗的120例患者的临床资料,根据化疗方案不同将其分为A组、B组和C组,每组40例。A组接受NabPCb方案,B组接受TCb方案,C组接受EC-T方案。对比三组患者的临床疗效、肿瘤标志物水平、中位无进展生存时间及生存率。结果A组的治疗总有效率为77.50%,高于B组、C组的67.50%、70.00%,组间差异有统计学意义(P<0.05)。A组的病理完全缓解率为36.67%,高于B组、C组的30.00%、28.33%,组间差异有统计学意义(P<0.05)。治疗后,三组的糖类抗原15-3、癌胚抗原及人表皮生长因子受体-2水平均低于治疗前,且A组各指标水平均低于B组、C组,组间差异有统计学意义(P<0.05)。A组的中位无进展生存时间长于B组、C组,组间差异有统计学意义(P<0.05)。A组的3年生存率高于B组、C组,组间差异有统计学意义(P<0.05)。结论不同新辅助化疗方案对三阴性乳腺癌患者的病理完全缓解率及生存指标有显著影响,其中NabPCb方案在提高病理完全缓解率、降低肿瘤标志物水平及延长无进展生存时间方面表现出显著优势,推荐在临床中优先考虑。Objective To compare the effects of different neoadjuvant chemotherapy regimens on pathological complete response rate in patients with triple-negative breast cancer.Methods The clinical data of one hundred and twenty patients diagnosed with triple-negative breast cancer and receiving neoadjuvant chemotherapy in Suzhou Ninth People's Hospital from January 2015 to April 2021 were retrospectively analyzed,and they were divided into group A、group B and group C according to different chemotherapy protocols,with 40 cases in each group.Group A accepted NabPCb regimen,group B accepted TCb regimen,and group C accepted EC-T regimen.The clinical efficacy,tumor marker levels,median progression-free survival time and survival rate of the three groups were compared.Results The total effective rate of group A was 77.50%,which was higher than 67.50% and 70.00% of group B and group C,and the difference between the groups was statistically significant(P<0.05).The pathological complete response rate of group A was 36.67%,which was higher than 30.00% and 28.33% of group B and group C,and the difference between the groups was statistically significant(P<0.05).After treatment,the levels of carbohydrate antigen 15-3,carcinoembryonic antigen and human epidermal growth factor receptor-2 in the three groups were lower than before treatment,and the levels of all indexes in group A were lower than those in group B and group C,and the differences between the groups were statistically significant(P<0.05).The median progression-free survival time of group A was longer than that of group B and group C,and the difference between the groups was statistically significant(P<0.05).The 3-year survival rate of group A was higher than that of group B and group C,and the difference between the groups was statistically significant(P<0.05).Conclusion Different neoadjuvant chemotherapy regiments have significant effects on pathological complete response rate and survival indicators of patients with triple-negative breast cancer,among which NabPCb regime

关 键 词：三阴性乳腺癌 新辅助化疗 疗效 病理完全缓解率 肿瘤标志物 生存率 

分 类 号：R737.9[医药卫生—肿瘤]