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作 者:牛梦瑶 武昕宜 宾凡淳 段琦 李腾[1,2] 郑美玲 Niu Mengyao;Wu Xinyi;Bin Fanchun;Duan Qi;Li Teng;Zheng Meiling(Laboratory of Organic NanoPhotonics,Technical Institute of Physicsand Chemistry,Chinese Academy of Sciences,Beijing 100190,China;School of Future Technology,University of Chinese Academy ofSciences,Beijing 101407,China)
机构地区:[1]中国科学院理化技术研究所有机纳米光子学实验室,北京100190 [2]中国科学院大学未来技术学院,北京101407
出 处:《中国激光》2024年第20期283-301,共19页Chinese Journal of Lasers
基 金:国家重点研发计划(2017YFB1104300);国家自然科学基金(61975213,61475164);中国科学院国际伙伴计划项目(GJHZ2021130)。
摘 要:拓扑结构能对细胞的行为进行调控,这对于组织和器官的形成以及整体结构和功能的发展至关重要。激光微纳加工技术的崭新应用正引领着细胞生物学研究的一场革命。激光技术的高精度和高可控性使得设计特定拓扑结构成为可能,为细胞工程、组织工程和再生医学等领域的发展提供了强大动力。本文综述了拓扑结构的设计要素、激光微纳加工技术,尤其是减材和增材这两种激光加工技术及其制备的拓扑结构在细胞生物学中的应用。本文旨在总结激光加工技术制备的拓扑结构及其在模拟细胞微环境、实现细胞导向和定位以及促进组织修复再生方面的应用,为生物医学工程的发展提供新的解决方案。Significance In biology,a topological structure refers to the specific spatial arrangement of the internal organization of a cell or organism,including factors such as the relative positions of the cells,nature of the connections,shape,and size.Topological structures can regulate the behaviors of cells and affect their biological processes,such as growth,differentiation,and migration,which are crucial for the formation of tissues and organs as well as the development of overall structure and function.Hence,they are capable of providing a new direction for future biomedical research with far-reaching implications for human health and disease treatment.Laser micro-nano fabrication technology is an advanced manufacturing technology that enables the fabrication of micro-nano scale structures by using laser beams for the precise fabrication of materials.The high-precision,high-resolution,and non-contact characteristics of laser fabrication technology make it possible to design specific topological structures.By precisely controlling the energy and focus of the laser,laser fabrication technology can fabricate a variety of topological surfaces on demand,and it shows unique potential in regulating cell proliferation,differentiation,migration,and adhesion.Intensive research in this field is expected to provide advanced technological tools as well as accelerate innovation and development in biomedical engineering.Many advances have been made in recent years regarding the fabrication of topological structures using laser fabrication techniques and their applications in cell biology.However,there are still challenges in the fabrication of large-area,high-complexity structures and the mechanisms of topological structures on different cell types.Therefore,it is necessary to summarize the existing relevant research progress to gain a more comprehensive understanding of the problems in this field,as this will be instructive for the future direction of the field.Progress First,the design elements of topological structures and the
分 类 号:V261.8[航空宇航科学与技术—航空宇航制造工程]
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