纤维化对肿瘤浸润免疫细胞的影响——“硬冷肿瘤”的形成  

The effects of fibrosis on tumor-infiltrating immune cells——the formation of"armored&cold tumors"

作　　者：梅杰 徐瑞 蔡芸 朱一超[3] Jie Mei;Rui Xu;Yun Cai;Yichao Zhu(The First Clinical Medicine College,Nanjing Medical University,Nanjing 211166,China;Department of Central Laboratory,Jintan Affiliated Hospital of Jiangsu University,Changzhou 210036,China;Department of Physiology,Nanjing Medical University,Nanjing 211166,China)

机构地区：[1]江苏南京医科大学第一临床医学院,南京211166 [2]江苏常州市金坛第一人民医院检验科,常州210036 [3]江苏南京医科大学生理学系,南京211166

出　　处：《中华细胞与干细胞杂志（电子版）》2024年第5期257-263,共7页Chinese Journal of Cell and Stem Cell（Electronic Edition）

基　　金：国家自然科学基金面上项目(82073194)。

摘　　要：实体瘤具有独特的细胞外基质,可以在很大程度上调控包括免疫逃逸在内的肿瘤细胞的恶性行为。大部分实体瘤会形成肿瘤纤维化,而这种特征主要由细胞外基质中的胶原蛋白所赋予。胶原蛋白是人体内含量最多的蛋白质之一,而肿瘤组织中胶原蛋白主要由肿瘤相关成纤维细胞合成,通过抑制多种肿瘤浸润免疫细胞在肿瘤免疫逃逸中发挥显著作用。胶原蛋白既可作为肿瘤患者预测预后的生物标志物,也可作为有效的肿瘤治疗靶点。本文综述肿瘤纤维化在肿瘤中的作用,特别是对浸润免疫细胞的影响,同时关注肿瘤纤维化的研究方法和治疗相关研究进展。此外,本文介绍由本课题组提出的基于胶原蛋白沉积与免疫细胞浸润的“胶原-免疫分型”及“硬冷肿瘤”的概念阐释。Solid tumors have the unique extracellular matrix that can largely regulate the malignant behavior of tumor cells,including immune escape.The majority of solid tumors can form tumor fibrosis,which is mainly conferred by collagen in the extracellular matrix.Collagen is one of the most abundant proteins in the human body and mainly produced by tumor-associated fibroblasts in tumor tissues,which plays a critical role in tumor immune escape by inhibiting a variety of tumorinfiltrating immune cells.Collagen can be used both as a biomarker for prognosis in cancer patients and as an effective target for cancer therapy.This review summarized the roles of tumor fibrosis in tumors,especially the effect on tumor-infiltrating immune cells,and focused on the research methods of tumor fibrosis and treatment-related research progress.In addition,this review introduces the interpretation of"immuno-collagenic subtypes"based on collagen deposition and immune activity and the concept of"armored&cold tumors"proposed by our research group.

关 键 词：纤维化 胶原蛋白 肿瘤浸润免疫细胞 硬冷肿瘤 

分 类 号：R730.51[医药卫生—肿瘤]