HIV治愈研究的伦理思考:价值与挑战  

Ethical Reflections on HIV Cure Research:Values and Challenges

作　　者：刘迪[1] 王赵琛[1] 翟晓梅[1] LIU Di;WANG Zhaochen;ZHAI Xiaomei(School of Population Medicine and Public Health,Chinese Academy of Medical Sciences/Peking Union Medical College,Beijing 100730,China)

机构地区：[1]中国医学科学院/北京协和医学院群医学及公共卫生学院,北京100730

出　　处：《医学与哲学》2024年第23期10-15,共6页Medicine and Philosophy

摘　　要：当前抗逆转录病毒疗法的局限性促使全球加速探索HIV治愈策略,然而该领域的快速发展也引发了复杂的伦理问题。首先对缓解和治愈、完全治愈和功能性治愈的概念进行了辨析,随后阐述了HIV治愈研究的独特价值,在个体层面上摆脱持续治疗负担和污名,在公共卫生层面上根本性降低传播风险、长远的社会经济效益以及缓解医疗资源紧张情况。最后,深入分析了研究过程中面临的伦理挑战与应对策略,包括治愈的认识论差异和“治愈误解”、研究参与者的公平选择以及伦理审查实施困境。通过前瞻性思考,以期能为HIV治愈研究的向善发展提供建议和参考。The limitations of current antiretroviral therapy have accelerated global efforts to explore HIV cure strategies;however,the rapid advancement in this field has also raised complex ethical issues.The article first clarifies the concepts of remission and cure,as well as sterilizing cure and functional cure.It then describes the unique value of HIV cure research.At the individual level,it can free people from continuous treatment burden and stigma.At the public health level,it can fundamentally reduce transmission risks,provide long-term socioeconomic benefits,and alleviate the strain on healthcare resources.Finally,the article provides an in-depth analysis of the ethical challenges and strategies encountered in the research process,including epistemological differences regarding cure,the"cure misconception",fair selection of research participants,and the implementation challenges of ethical review.Through forward-looking reflections,the article aims to provide insights and recommendations to support the ethical and beneficial development of HIV cure research.

关 键 词：艾滋病 HIV治愈研究 伦理 

分 类 号：R-05[医药卫生]