应用多点可穿戴设备定量评估早期帕金森病运动障碍特征研究  

A study on the quantitatively evaluation of motor dysfunction characteristics in early Parkinson’s disease by a multi⁃point wearable device

作　　者：丁晨琛 刘卫国[2] DING Chenchen;LIU Weiguo(Department of Neurology,the Fourth Affiliated Hospital of Nanjing Medical University,Nanjing 210031;Department of Neurology,the Affiliated Brain Hospital of Nanjing Medical University,Nanjing 210029,China)

机构地区：[1]南京医科大学第四附属医院神经内科,江苏南京210031 [2]南京医科大学附属脑科医院神经内科,江苏南京210000

出　　处：《南京医科大学学报（自然科学版）》2024年第12期1708-1714,1722,共8页Journal of Nanjing Medical University(Natural Sciences)

基　　金：江苏省科技计划项目重点项目(BE2019611)。

摘　　要：目的:基于统一帕金森病评分量表(unified Parkinson’s disease rating scaleⅢ,UPDRSⅢ)的指定动作评估多点可穿戴设备辅助早期帕金森病(Parkinson’s disease,PD)诊断的价值。方法:本研究共纳入54例受试者,分为早期PD组(n=30,UPDRSⅢ<30分)和正常对照组(n=24),并在多点可穿戴设备下完成UPDRSⅢ要求的指定动作。使用10个惯性传感器收集受试者在完成动作时胸、腰、膝关节、肘关节、踝关节及双足部等部位的角速度、加速度等信息。比较各组间指定动作的运动参数,采用支持向量机和十折交叉验证计算可区分两组的最佳模型并评估其诊断效能。结果:早期PD组与正常对照组完成各UPDRSⅢ指定动作的可穿戴设备运动参数差异有统计学意义(P<0.05)。其中言语动作区分两组的准确性最高,为0.907。与上半身动作组相比,下半身动作组与全身动作组的一致性、敏感性及准确性均较高,能特异性地识别早期PD患者的运动障碍。结论:多点可穿戴设备能客观评估早期PD患者运动障碍特征,可作为早期PD辅助诊断和量化评估的工具。Objective:To evaluate the potential of using a multi⁃point wearable device in facilitating early diagnosis of Parkinson’s disease(PD)with the unified Parkinson’s disease rating scaleⅢ(UPDRSⅢ).Methods:A total of 54 subjects were recruited in this study.They were divided into the early PD group(n=30,UPDRSⅢ<30 points)and the normal control group(n=24).Each subject wore a multi⁃point wearable device when performing the standard actions required by the UPDRSⅢ.Ten inertial sensors were employed to collect data on angular speed,acceleration,and other parameters from the subject’s chest,waist,knee joints,elbow joints,ankle joints,and both feet.The motor parameters of specific movements were compared between the two groups,and a support vector machine within ten⁃fold cross⁃validation was used to calculate the optimal model to distinguish the two groups and assess its diagnostic potentials.Results:There were significant statistical differences in the motion parameters of wearable devices in the early PD group and the normal control group after completing the specified actions of UPDRSⅢ(P<0.05).The accuracy of speech action between the two groups was the highest,reaching 0.907.Compared to the upper body movements,the lower body movement and the whole body movements had higher consistency,sensitivity and accuracy,allowing for specific identification of motor dysfunction in early PD patients.Conclusion:Multi⁃point wearable devices can objectively evaluate the characteristics of movement disorders in early PD patients,and can be used as a tool for auxiliary diagnosis and quantitative evaluation of early PD.

关 键 词：早期帕金森病 运动障碍 多点可穿戴设备 定量评估 

分 类 号：R742.5[医药卫生—神经病学与精神病学]