复方莪术散治疗恶性肿瘤高凝状态的临床研究  

Compound Zedoary Turmeric Powder for Treating Hypercoagulability of Malignant Tumor

作　　者：郝家鹏 杨天明 杜平 陈燕 郭茂新 李艳 HAO Jiapeng;YANG Tianming;DU Ping;CHEN Yan;GUO Maoxin;LI Yan(Bijie Traditional Chinese Medicine Hospital,Guizhou Bijie 551700,China;Guizhou University of Traditional Chinese Medicine,Guizhou Guiyang 550000,China)

机构地区：[1]贵州省毕节市中医医院,贵州毕节551700 [2]贵州中医药大学,贵州贵阳550000

出　　处：《中医药临床杂志》2024年第11期2196-2200,共5页Clinical Journal of Traditional Chinese Medicine

基　　金：贵州省毕节市科技局联合基金资助项目(毕科联合字Z[2019]4号)。

摘　　要：目的:观察复方莪术散改善恶性肿瘤高凝状态的临床疗效;方法:收集恶性肿瘤并血液高凝状态的患者60例,随机分为对照组30例(脱落1例),剩余29例,治疗组30例,对照组采用常规对症支持治疗,治疗组在常规对症支持治疗的基础上加用复方莪术散,以两周为一个治疗周期;检测治疗前后2组患者外周血的D-二聚体(DD)、纤维蛋白原含量(FIB)、血浆凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、血小板计数,并记录中医证候积分,生活质量评分;结果:复方莪术散可以降低恶性肿瘤并血液高凝状态的患者的DD,改善FIB、PT、APTT,提高生活质量,说明复方莪术散治疗恶性肿瘤并血液高凝状态有效。Objective:To observe the clinical efficacy of compound curcuma powder in improving the hypercoagulable state of malignant tumors.Methods:A total of 60 patients with malignant tumors and hypercoagulable state were collected and randomly divided into a control group of 30 cases(1 case dropped out)and the remaining 29 cases,and a treatment group of 30 cases.The control group received conventional symptomatic supportive treatment,and the treatment group was treated with compound curcuma powder on the basis of conventional symptomatic supportive treatment,with a treatment cycle of two weeks.The peripheral blood D-dimer(DD),fibrinogen content(FIB),plasma prothrombin time(PT),activated partial thromboplastin time(APTT),and platelet count of the two groups of patients before and after treatment were detected,and the TCM syndrome score and quality of life score were recorded.Results:Compound curcuma powder can reduce DD,improve FIB,PT,APTT,and improve the quality of life of patients with malignant tumors and hypercoagulable state,indicating that compound curcuma powder is effective in treating malignant tumors and hypercoagulable state.

关 键 词：复方莪术散 恶性肿瘤 高凝状态 

分 类 号：R73[医药卫生—肿瘤]