干扰素刺激基因15在消化道恶性肿瘤中的作用及机制研究进展  

Advances in the role and mechanism of ISG15 in malignant tumours of the gastrointestinal tract

作　　者：江平 罗晓琴 翟少倩 曹成珠 苏占海 JIANG Ping;LUO Xiaoqin;ZHAI Shaoqian;CAO Chengzhu;SU Zhanhai(College of Basic Medical Sciences Qinghai University,Xining 810001,Qinghai,China)

机构地区：[1]青海大学医学院基础医学部,青海西宁810001 [2]青海省人民医院,青海西宁810006

出　　处：《实用医学杂志》2024年第23期3394-3404,共11页The Journal of Practical Medicine

基　　金：国家自然科学基金项目(编号:32360242);青海省自然科学基金面上项目(编号:2023-ZJ-932M)。

摘　　要：干扰素刺激基因15(interferonstimulating gene 15, ISG15)是一种由Ⅰ型干扰素诱导的蛋白和泛素样分子,属于泛素样蛋白超家族。ISG15在多种恶性肿瘤中高表达,且与肿瘤发生、发展密切相关,然而其具体调控机制仍未阐明。本研究就ISG15在肝癌、食管癌、胃癌、结直肠癌和其他消化道恶性肿瘤在肿瘤发生、发展、预后及药物治疗等方面的研究进行总结,旨在给消化道恶性肿瘤治疗新靶点及预后判断带来新选择。Interferon‐stimulating gene 15(ISG15),an ubiquitin‐like molecule belonging to the superfamily of ubiquitin‐like proteins,is highly expressed in various malignant tumors and induced by type I interferon.However,its specific regulatory mechanism remains unclear.Numerous studies have demonstrated its close association with tumorigenesis and development.In this study,we provide a comprehensive review on the role of ISG15 protein in hepatocellular carcinoma,esophageal carcinoma,gastric carcinoma,colorectal carcinoma,and other cancers.Our aim is to identify new therapeutic targets for gastrointestinal malignancies and improve prognostic assessment.

关 键 词：ISG15 消化道恶性肿瘤 治疗新靶点 

分 类 号：R735[医药卫生—肿瘤]