细胞焦亡在癌症治疗中的双重作用与新策略  

Dual role and new strategies of pyroptosis in cancer therapy

作　　者：肖潇 龙方懿 王刚 XIAO Xiao;LONG Fangyi;WANG Gang(Department of Gynecology,Sichuan Provincial Women's and Children's Hospital/the Affiliated Women's and Chil-dren's Hospital of Chengdu Medical College,Chengdu 610045,Sichuan,China)

机构地区：[1]四川省妇女儿童医院/成都医学院附属妇女儿童医院妇科,四川成都610045 [2]四川省妇女儿童医院/成都医学院附属妇女儿童医院实验医学中心,四川成都610045

出　　处：《实用医学杂志》2024年第23期3419-3426,共8页The Journal of Practical Medicine

基　　金：四川省科技计划项目(编号:2022YFS0252)。

摘　　要：细胞焦亡(pyroptosis)是一种具有炎症特征的程序性细胞死亡方式,近年来在生物医学领域引起了广泛关注。细胞焦亡在激活宿主防御、促进炎症反应、调节免疫应答及影响肿瘤微环境等方面发挥重要作用。在癌症的研究中,细胞焦亡的双重作用尤为显著,它既可以抑制肿瘤生长,也能在某些情况下促进肿瘤的发展。此外,对细胞焦亡的研究为癌症治疗提供了新的视角,特别是在增强传统放化疗效果、促进抗肿瘤免疫反应以及开发纳米治疗策略方面,细胞焦亡的机制为新研究途径提供了基础。该文综述了细胞焦亡在癌症进展中的调控作用,以及其作为潜在抗癌策略的理论基础和实际应用进展,期望为未来癌症治疗策略的发展提供新的思路和方向。Pyroptosis is a form of programmed cell death with inflammatory characteristics,which has attracted wide attention in the biomedical field in recent years.Pyroptosis plays a crucial role in activating host defenses,promoting inflammatory responses,regulating immune responses,and influencing the tumor microenvi⁃ronment.In cancer research,the dual role of pyroptosis is particularly significant,which can both inhibit tumor growth and promote tumor development in certain instances.Furthermore,research on pyroptosis offers new per⁃spectives for cancer treatment,particularly in enhancing the efficacy of traditional chemoradiotherapy,boosting anti-tumor immune responses,and applying nanotherapeutic strategies.This article reviews the regulatory role of pyroptosis in cancer progression,as well as its theoretical basis and practical applications as a potential anti-cancer strategy,with the aim of providing new insights and directions for the development of cancer treatment strategies in the future.

关 键 词：细胞焦亡 促进癌症进展 抑制肿瘤生长 增强放化疗敏感性 调节免疫应答 纳米医学 

分 类 号：R730.5[医药卫生—肿瘤]