年龄相关的B细胞的基础与临床研究进展  

Advances in basic and clinical studies of age-associated B cells

作　　者：肖易沁文 陈紫薇 李菲[2,3,4] 王诗轩[2,3,4] XIAO Yi-qin-wen;CHEN Zi-wei;LI Fei;WANG Shi-xuan(Department of Rheumatology and Immunology,Rongjun Hospital of Zhejiang,Jiaxing 314001,China;Center of Hematology,The First Affiliated Hospital of Nanchang University,Nanchang 330006,China;Clinical Research Center of Hematology of Jiangxi Province,Nanchang 330006,China;Institute of Lymphoma of Nanchang University,Nanchang 330006,China;Huangshi Central Hospital,Huangshi 435000,China)

机构地区：[1]浙江省荣军医院风湿免疫科,嘉兴314001 [2]南昌大学第一附属医院血液病中心,南昌330006 [3]江西省血液病临床医学研究中心,南昌330006 [4]南昌大学淋巴肿瘤疾病研究所,南昌330006 [5]黄石市中心医院,黄石435000

出　　处：《现代免疫学》2024年第6期548-554,共7页Current Immunology

基　　金：国家自然科学基金(82060030);江西省科技创新基地计划-江西省血液病临床医学研究中心(20212BCG74001,20211ZDG02006);江西省中医药管理局科技计划(2020B0361)。

摘　　要：年龄相关的B细胞(age-associated B cells,ABC)是近年发现的一种新型B细胞亚群,随年龄增长在脾脏中不断积累。这些细胞有独特的细胞表型和转录特征。ABC高表达髓系标记CD11c和转录因子T-bet,在Th1细胞因子和TLR7和(或)TLR9的刺激下分化增殖,具有分化为浆细胞产生抗体、分泌细胞因子、呈递抗原等功能。ABC在免疫衰老、自身免疫病等方面发挥重要作用,该文旨在介绍ABC的表型特征、起源、解剖分布、分化调控机制与功能,阐明其在免疫衰老和自身免疫病中的作用,有助于为临床治疗提供新靶点。Age-associated B cell(ABC)is a new B cell subset discovered in recent years,which accumulates in spleen with age.This type of cell has unique cellular phenotypes and transcriptional features.ABC highly expresses myeloid marker CD11c and transcription factor T-bet,and differentiates and proliferates upon the stimulation of Th1 cytokines and TLR7 and/or TLR9.It can differentiate into plasma cells to produce antibodies,secrete cytokines,and present antigens.ABC plays an important role in immune aging and autoimmune disease.This review aims to introduce the phenotypic characteristics,origin,anatomical distribution,differentiation regulation mechanism,and function of ABC,clarify its role in immune aging and autoimmune diseases,and provide a new target for clinical treatment.

关 键 词：年龄相关的B细胞 免疫衰老 自身免疫 分子靶向治疗 

分 类 号：R735.3[医药卫生—肿瘤] R392.12[医药卫生—临床医学]