肺腺癌组织中卵泡抑素样3蛋白的表达及其临床意义  

Expression and clinical significance of FSTL3 protein in lung adenocarcinoma

作　　者：刘政宏[1] 袁春銮[1] 高佳 LIU Zhenghong;YUAN Chunluan;GAO Jia(Department of Oncology,the First People’s Hospital of Lianyungang City,Jiangsu 222000,China)

机构地区：[1]连云港市第一人民医院肿瘤科,222000

出　　处：《临床外科杂志》2024年第11期1166-1169,共4页Journal of Clinical Surgery

基　　金：江苏省第十四期“六大人才高峰”资助项目(SWYY-200)。

摘　　要：目的探讨肺腺癌(LUAD)组织中卵泡抑素样3(FSTL3)蛋白的表达水平与病人临床病理指标和预后的关系。方法回顾性纳入2015年1月~2022年11月我院接受肺癌根治性切除术治疗的LUAD病人268例,免疫组化SP法检测LUAD组织和配对癌旁正常组织中FSTL3蛋白表达情况,比较不同FSTL3表达水平的病人临床病理指标和总生存期(OS)的差异。采用Cox回归模型分析LUAD病人术后OS的影响因素。结果LUAD组织中FSTL3蛋白的高表达率(55.97%)高于癌旁组织(33.21%)(χ2=28.098,P<0.05)。不同分化程度、淋巴结转移、远处转移情况、TNM分期的LUAD病人之间FSTL3蛋白表达水平的差异有统计学意义(P<0.05)。FSTL3蛋白高表达者OS率显著低于低表达者(χ2=4.706,P=0.030)。Cox回归分析表明,淋巴结转移、远处转移、TNM分期Ⅲ期和FSTL3高表达是影响LUAD病人术后OS的独立危险因素(P<0.05)。结论FSTL3蛋白表达在LUAD组织中显著上升,且与分化程度、淋巴结转移、远处转移情况、TNM分期相关;FSTL3高表达是影响LUAD病人术后预后的独立危险因素。FSTL3蛋白具有成为LUAD早期诊断和预后预测生物标志物的潜力。Objective To investigate the expression of Follistatin-like 3(FSTL3)protein in lung adenocarcinoma(LUAD)tissue and its association with clinical pathological indicators and prognosis.Methods A total of 268 LUAD patients who underwent radical resection of lung cancer were collected,and the expression of FSTL3 protein in LUAD and paired paracancerous normal tissues was detected using immunohistochemistry.The clinical pathological indicators and overall survival(OS)rate were compared among patients with different levels of FSTL3 expression.Cox regression model was used to analyze the influencing factors of postoperative OS in LUAD patients.Results The high expression rate of FSTL3 protein in LUAD tissue(55.97%)was significantly higher than that in paracancerous tissues(33.21%)(χ2=28.098,P<0.001).The expression level of FSTL3 protein showed significant differences among LUAD patients with different degrees of differentiation,lymph node metastasis,distant metastasis,and TNM stage(all P<0.05).The OS rate of patients with high FSTL3 protein expression was significantly lower than that of patients with low expression(χ2=4.706,P=0.030).Cox regression analysis indicated that lymph node metastasis,distant metastasis,TNM stagesⅢ,and high expression of FSTL3 were independent risk factors affecting postoperative OS in LUAD patients(all P<0.05).Conclusion The expression of FSTL3 protein significantly increased in LUAD tissue,and it was associated with tumor differentiation,lymph node metastasis,distant metastasis,and TNM stage.High expression of FSTL3 was an independent risk factor affecting the postoperative prognosis of LUAD patients.FSTL3 protein has the potential to become a biomarker for early diagnosis and prognostic prediction of LUAD.

关 键 词：卵泡抑素样3 肺腺癌 临床病理指标 预后 影响因素 

分 类 号：R734.2[医药卫生—肿瘤]