血清骨桥蛋白,血管生成素样蛋白8水平与原发性肝癌病人介入治疗后肝纤维化的相关性  

Correlation between serum OPN,ANGPTL8 levels in patients with primary liver cancer and liver fibrosis after interventional therapy

作　　者：李军波 呼国庆[1] 夏化文 LI Junbo;HU Guoqing;XIA Huawen(Department of Interventional Vascular Surgery,the First Hospital of Handan City,Hebei 056000,China)

机构地区：[1]河北省邯郸市第一医院介入血管外科,056000

出　　处：《临床外科杂志》2024年第11期1175-1178,共4页Journal of Clinical Surgery

基　　金：2022年度河北省中医药类科研计划课题(2022664)。

摘　　要：目的探讨原发性肝癌(PHC)病人血清骨桥蛋白(OPN)、血管生成素样蛋白8(ANGPTL8)水平与经导管动脉化疗栓塞术(TACE)后肝纤维化(HF)的相关性。方法2021年3月~2023年6月期间收治的PHC病人166例,根据介入治疗后是否发生HF分为两组,其中发生HF的病人92例,为观察组,未发生HF的病人74例,为对照组;酶联免疫吸附法(ELISA)测定血清OPN、ANGPTL8水平并分析OPN、ANGPTL8水平对HF的预测价值。采用Pearson相关性分析OPN、ANGPTL8水平与生化指标的相关性;采用多因素Logistics回归分析影响HF发生的因素;采用ROC曲线分析OPN、ANGPTL8对HF的预测价值。结果观察组血清OPN[(74.56±11.56)ng/ml]、ANGPTL[(42.78±5.23)ng/ml]、ALT[(62.24±9.56)U/L]、AST[(42.88±8.23)U/L]、HA[(252.98±52.44)ng/L]、LN[(152.64±26.45)ng/L]、PCⅢ[(16.54±3.46)ng/L]、Ⅳ-C[(152.78±21.23)ng/L]水平明显高于对照组[(57.89±9.68)ng/ml、(35.46±4.78)ng/ml、(49.46±7.46)U/L、(31.48±7.26)U/L、(192.56±23.88)ng/L、(124.48±11.23)ng/L、(11.26±2.23)ng/L、(126.45±18.56)ng/L],两组比较,差异有统计学意义(P<0.05)。血清OPN、ANGPTL8及二者联合预测HF发生的AUC分别为0.914、0.920、0.978,OPN联合ANGPTL8预测HF发生的AUC高于二者分别单独预测(P<0.05)。结论PHC病人血清OPN、ANGPTL8水平与HF的发生密切相关,二者是HF发生的影响因素,可作为预测HF发生的指标。Objective To investigate the correlation between serum osteoblastin(OPN)and angiopoietin-like protein 8(ANGPTL8)levels and hepatic fibrosis(HF)after interventional therapy-transcatheter arterial chemoembolisation(TACE)in patients with primary hepatocellular carcinoma(PHC).Methods 166 patients with PHC admitted between March 2021 and June 2023 were selected and divided into 92 cases with HF(observation group)and 74 cases without HF(control group)according to whether or not HF occurred after interventional therapy;enzyme-linked immunosorbent assay(ELISA)was used to determine the serum OPN and ANGPTL8 levels and to analyse the predictive value of the OPN and ANGPTL8 levels on HF.Pearson correlation was used to analyze the correlation between OPN and ANGPTL8 levels and biochemical indexes.The factors influencing the occurrence of HF were analyzed by multi-factor Logistics regression.ROC curve was used to analyze the predictive value of OPN and ANGPTL8 for HF.Results Serum OPN[(74.56±11.56)ng/ml],ANGPTL[(42.78±5.23)ng/ml],ALT[(62.24±9.56)U/L],AST[(42.88±8.23)U/L],HA[(252.98±52.44)ng/L],LN[(152.64±26.45)ng/L],PCⅢ[(16.54±3.46)ng/L]andⅣ-C[(152.78±21.23)ng/L]in observation group were significantly higher than the control group[(57.89±9.68)ng/ml,(35.46±4.78)ng/ml,(49.46±7.46)U/L,(31.48±7.26)U/L,(192.56±23.88)ng/L,(124.48±11.23)ng/L,(11.26±2.23)ng/L and(126.45±18.56)ng/L].The differences between the two groups were statistically significant(P<0.05).The AUC of serum OPN,ANGPTL8 and the combination of the two in predicting the occurrence of HF were 0.914,0.920 and 0.978,respectively,and the AUC of OPN combined with ANGPTL8 in predicting the occurrence of HF was higher than the AUC of the two separately(P<0.05).Conclusion The levels of serum OPN and ANGPTL8 of patients with PHC are closely associated with the occurrence of HF,and the two are HF occurrence influencing factors and can be used as indicators to predict the occurrence of HF.

关 键 词：原发性肝癌 介入治疗 肝纤维化 骨桥蛋白 血管生成素样蛋白8 

分 类 号：R735.7[医药卫生—肿瘤]