出 处:《中国现代医药杂志》2024年第11期59-64,共6页Modern Medicine Journal of China
摘 要:目的探讨胸腔积液中血管内皮生长因子(VEGF)水平及表皮生长因子受体(EGFR)基因突变与非小细胞肺癌(NSCLC)患者病理特征、靶向治疗效果的关系。方法选取2021年1月~2024年1月在我院治疗的NSCLC患者100例,分析不同临床病理特征患者胸腔积液中VEGF水平及EGFR基因突变差异;根据治疗方案,将EGFR基因突变患者分为靶向治疗组(n=24)和常规化疗组(n=22),分析靶向治疗组和常规化疗组治疗疗效差异,同时分析靶向治疗组不同疗效患者胸腔积液中VEGF水平差异。结果低分化患者胸腔积液中VEGF水平明显高于中高分化患者(P<0.05);TNM分期Ⅲ~Ⅳ期患者胸腔积液中VEGF水平明显高于Ⅰ~Ⅱ期患者(P<0.05);有淋巴结转移患者胸腔积液中VEGF水平明显高于无淋巴结转移患者(P<0.05);女性、无吸烟史、腺癌患者的胸腔积液中EGFR基因突变率高于男性、有吸烟史、非腺癌患者(P<0.05);靶向治疗组疗效优于常规化疗组(P<0.05),靶向治疗组客观缓解率(ORR)高于常规化疗组,但差异无统计学意义(P>0.05);靶向治疗组部分缓解(PR)患者胸腔积液中VEGF水平明显低于非PR患者(P<0.05)。结论胸腔积液中VEGF水平与NSCLC患者分化程度、TNM分期和淋巴结转移有关,EGFR基因突变与性别、吸烟及病理类型有关;在EGFR基因突变患者中,靶向治疗效果明显优于常规化疗,同时靶向治疗效果与胸腔积液中VEGF水平可能有关。Objective To explore the relationship between vascular endothelial growth factor(VEGF)levels and epidermal growth factor receptor(EGFR)gene mutations in pleural effusion with the pathological characteristics and efficacy of targeted treatment in non-small cell lung cancer(NSCLC)patients.Methods A total of 100 NSCLC patients treated in our hospital from Jan 2021 to Jan 2024 were selected for analysis of VEGF levels and EGFR gene mutations in pleural effusion among patients with different clinical pathological characteristics.According to the treatment plan,EGFR gene mutation patients were divided into a targeted therapy group(n=24)and a conventional chemotherapy group(n=22)to assess efficacy differences in treatment.At the same time,the differences in VEGF levels in pleural effusion of patients with different therapeutic effects in the targeted therapy group were analyzed.Results The VEGF level in pleural effusion of patients with poorly differentiated was significantly higher than that of patients with moderately to highly differentiated(P<0.05).The VEGF level in pleural effusion of TNM stageⅢ~Ⅳpatients was significantly higher than that of stageⅠ~Ⅱpatients(P<0.05).The VEGF level in pleural effusion of patients with lymph node metastasis was significantly higher than that of patients without lymph node metastasis(P<0.05).The EGFR gene mutation rate in pleural effusion of female,non-smoking and adenocarcinoma patients was higher than that of male,smoking,and non adenocarcinoma patients(P<0.05).The efficacy effect of the targeted therapy group was better than that of the conventional chemotherapy group(P<0.05),and the objective response rate(ORR)of the targeted therapy group was higher than that of the conventional chemotherapy group,but the difference was not statistically significant(P>0.05).The VEGF level in pleural effusion of partially relieved(PR)patients in the targeted therapy group was significantly lower than that of non PR patients(P<0.05).Conclusion VEGF levels in pleural effusion is related to
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