锌转运体ZIP13与疾病  

Zinc transporter ZIP13 and diseases

作　　者：李欢欢 马婧 邓佩佩 刘璇 王树松 LI Huanhuan;MA Jing;DENG Peipei;LIU Xuan;WANG Shusong(Hebei Key Laboratory of Reproductive Medicine,Hebei Reproductive Health Hospital,Shijiazhuang 050071,China)

机构地区：[1]河北省生殖健康医院、河北省生殖医学重点实验室,河北石家庄050071

出　　处：《基础医学与临床》2024年第12期1712-1716,共5页Basic and Clinical Medicine

基　　金：河北省自然科学基金(H2022314001);河北省医学科学研究课题计划(20231201);2022年河北省政府资助临床优秀人才项目。

摘　　要：锌是蛋白质合成、细胞增殖、迁移和自噬等多种生物过程的重要调节因子。锌转运体ZIP13(SLC39A13)是一种同源二聚体的金属转运蛋白,参与机体锌、铁和钙等离子的转运。ZIP13通过调节锌稳态参与疾病调控,如ZIP13在结缔组织发育中的关键作用至少部分是因为它参与了BMP/TGF-β信号通路,ZIP13通过激活Src/FAK信号通路促进人卵巢癌细胞的转移和ZIP13通过调节C/EBP-β表达来抑制米色脂肪细胞的生物发生和能量消耗等。Zinc is an important regulator of various biological processes such as protein synthesis,cell proliferation,migration and autophagy.The zinc transporter ZIP13(SLC39A13)is a homodimeric metal transporter functioning in transport of zinc,iron,and calcium plasma in body.ZIP13 is involved in disease by regulating zinc homeostasis,such as the key role of ZIP13 in connective tissue development because it is involved in the BMP/TGF-βsignaling pathway.ZIP13 promotes the metastasis of human ovarian cancer cells by activating the Src/FAK signaling pathway and ZIP13 inhibits the biogenesis and energy expenditure of beige adipocytes by regulating C/EBP-βexpression.

关 键 词：锌转运体 ZIP13 Ehlers-Danlos综合症 金属离子转运 

分 类 号：R363[医药卫生—病理学]