奥美拉唑联合克拉霉素及阿莫西林对老年消化性溃疡患者免疫功能及血清炎症因子的影响  

Effects of omeprazole combined with clarithromycin and amoxicillin on immune function and serum inflammatory factors in elderly patients with peptic ulcer

作　　者：梁超 田浩 石岩[1] LIANG Chao;TIAN Hao;SHI Yan(Department of Pharmacy,Daqing Oilfield General Hospital,Daqing,Heilongjiang,163000,China)

机构地区：[1]大庆油田总医院药剂科,黑龙江大庆163000

出　　处：《当代医学》2024年第18期74-77,共4页Contemporary Medicine

摘　　要：目的探究奥美拉唑联合克拉霉素及阿莫西林对老年消化性溃疡患者免疫功能及血清炎症因子的影响。方法选取2020年6月至2021年6月大庆油田总医院收治的60例老年消化性溃疡患者作为研究对象,按照随机数字表法分为对照组与观察组,每组30例。对照组口服奥美拉唑,观察组在对照组基础上联合克拉霉素与阿莫西林治疗,比较两组临床疗效、胃泌素、胃内酸碱值、免疫功能、血清炎症因子及不良反应发生情况。结果观察组治疗总有效率为96.67%,高于对照组的73.33%,差异有统计学意义(P<0.05)。治疗后,两组胃泌素均低于治疗前,胃内酸碱值均高于治疗前,且观察组胃泌素水平低于对照组,胃内酸碱值高于对照组,差异有统计学意义(P<0.05)。治疗后,两组红细胞C3b受体活性率(red blood cell Complement 3b receptor rosette rate,RBC-C3bRR)均高于治疗前,红细胞黏附免疫复合物率(red blood cell immune complex rosette rate,RBC-ICRRR)均低于治疗前,且观察组RBC-C3bRR高于对照组,RBC-ICRRR低于对照组,差异有统计学意义(P<0.05)。治疗后,两组C反应蛋白(C-reactive protein,CRP)、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)、白细胞介素-8(interleukin8,IL-8)、白细胞介素-6(interleukin-6,IL-6)水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较差异无统计学意义。结论奥美拉唑与克拉霉素及阿莫西林治疗老年消化性溃疡患者疗效显著,能有效提高胃泌素水平,降低胃内酸碱值,改善患者免疫功能,减轻炎症反应,且安全性高,值得临床推广应用。Objective To investigate the effects of omeprazole combined with clarithromycin and amoxicillin on immune function and serum inflammatory factors in elderly patients with peptic ulcer.Methods 60 elderly patients with peptic ulcer admitted to Daqing Oilfield General Hospital from June 2020 to June 2021 were selected as the reseach subjects,and they were divided into the control group and the observation group according to the random number table method,with 30 cases in each group.The control group was treated with omeprazole orally,and the observation group was treated with clarithromycin and amoxicillin.The clinical efficacy,gastrin,intragastric pH,immune function,serum inflammatory factors and adverse reactions were compared between the two groups.Results The total effective rate in the observation group was 96.67%,which was higher than 73.33%in the control group,the difference was statistically significant(P<0.05).After treatment,the level of gastrin of the two groups were lower than before treatment,gastric pH were higher than before treatment,and gastrin in the observation group was lower than the control group,gastric pH was higher than the control group,the differences were statistically significant(P<0.05).After treatment,the activity rate of red blood cell C3b receptor(RBC-C3bRR)of the two groups were lower than before treatment,and the rate of red blood cell adhesion immune complex(RBCICRRR)of the two groups were higher than before treatment,and the RBC-C3bRR in the observation group was higher than that in the control group,and the RBC-ICRRR was lower than that in the control group,and the differences were statistically significant(P<0.05).After treatment,the levels of C-reactive protein(CRP),tumor necrosis factor-α(TNF-α),interleukin-8(IL-8)and interleukin-6(IL-6)of the two groups were lower than before treatment,and the observation group was lower than the control group,and the differences were statistically significant(P<0.05).There was no significant difference in the occurrence of adverse reactio

关 键 词：消化性溃疡 奥美拉唑 克拉霉素 阿莫西林 胃泌素 免疫功能 炎症因子 

分 类 号：R573.1[医药卫生—消化系统]