原发性胃淋巴瘤的临床病理特征及患者预后的影响因素分析  

Analysis of clinicopathological characteristics and influencing factors in patients with primary gastric lymphoma

作　　者：张园园[1] 李宏涛[1] 甘红军[1] ZHANG Yuanyuan;LI Hongtao;GAN Hongjun(Department of Pathology,Fengcheng People's Hospital,Yichun,Jiangxi,331100,China)

机构地区：[1]丰城市人民医院病理科,江西宜春331100

出　　处：《当代医学》2024年第18期166-169,共4页Contemporary Medicine

摘　　要：目的分析原发性胃淋巴瘤临床病理特征及预后的影响因素。方法回顾性分析2019年1月至2021年12月丰城市人民医院收治的80例原发性胃淋巴瘤患者的临床资料,根据3年生存情况分为生存组(n=42)与死亡组(n=38),比较两组病理特征,采用多因素Logistic回归分析原发性胃淋巴瘤患者3年死亡的影响因素。结果生存组与死亡组临床表现、病变类型、病变部位、血清β_(2)微球蛋白(β_(2)-microglobulin,β_(2)-MG)水平比较差异无统计学意义;生存组与死亡组性别、年龄、乳酸脱氢酶(lactate dehydrogenase,LDH)水平、Lugano分期、病理分型、国际预后指数(internationalprognostic index,IPI)评分、治疗方案比较差异有统计学意义(P<0.05)。Logistic多元回归分析结果显示,年龄≥60岁、病理分型为T细胞源性、治疗方案为单纯手术、Lugano分期为ⅡE~Ⅳ期、IPI评分≥3分、LDH水平升高是原发性胃淋巴瘤患者3年死亡的危险因素(P<0.05)。结论年龄高、病理分型为T细胞源性、单纯手术、Lugano分期增加、IPI评分增加、LDH水平升高均会影响原发性胃淋巴瘤患者3年生存率,需准确评估存在上述危险因素原发性胃淋巴瘤患者的治疗方案,必要时可通过手术联合化疗治疗,以保证治疗准确性,延长患者生存期。Objective To analyze the clinicopathological characteristics and influencing factors in patients with primary gastric lymphoma Methods The clinical data of 80 patients with primary gastric lymphoma admitted to Fengcheng People's Hospital from January 2019 to December 2021 were retrospectively analyzed,they were divided into the survival group(n=42)and the death group(n=38)based on their 3-year survival status.The pathological characteristics were compared between the two groups,and multiple Logistic regression was used to analyze the influencing factors of 3-year death in patients with primary gastric lymphoma.Results There were no significant differences in clinical manifestations,lesion types,lesion sites and serum levels ofβ_(2)-microglobulin(β_(2)-MG)between the survival group and the death group;there were significant differences in gender,age,lactate dehydrogenase(LDH)level,Lugano stage,pathological classification,internationalprognostic index,survival and death groups,international prognostic index(IPI)score and treatment planbetween the survival group and the death group(P<0.05).The results of multiple Logistic regres-sion analysis showed that age≥60 years,pathological classification as T-cell derived,treatment plan as simple surgery,Lugano stageⅡE-Ⅳ,IPI score≥3 scores,and elevated LDH level were risk factors for 3-year mortality in patients with primary gastric lymphoma(P<0.05).Conclusion Advanced age,pathological classification as T-cell derived,simple surgery,increased Lugano staging,elevated IPI score and elevated LDH level can all affect the 3-year survival rate of patients with primary gastric lymphoma,it is necessary to accurately evaluate the treatment plan for patients with primary gastric lymphoma who have the above risk factors.If necessary,surgery combined with chemotherapy can be used to ensure treatment accuracy and prolong patient survival.

关 键 词：原发性胃淋巴瘤 临床病理特征 预后 

分 类 号：R735.2[医药卫生—肿瘤]