甲亢性肝病患者血清学指标检验结果及临床价值分析  

Analysis of Serological Test Results and Clinical Value in Patients with Hyperthyroid-related Liver Disease

作　　者：李坤朋 范卉 焦煜瑾 王艳[1] LI Kunpeng;FAN Hui;JIAO Yujin;WANG Yan(Department of Laboratory Medicine,Second People’s Hospital of Nanyang,Nanyang Henan 473000,China)

机构地区：[1]南阳市第二人民医院检验科,河南南阳473000

出　　处：《临床研究》2024年第12期133-135,共3页Clinical Research

摘　　要：目的分析甲亢性肝病患者血清学指标检验的临床价值。方法筛选南阳市第二人民医院2022年5月至2023年12月收治的82例甲亢性肝病患者设定为A组,82例肝功能正常的甲亢患者设定为B组,82例院内健康体检人群设定为C组,均检测血清肝功能指标[丙氨酸氨基转移酶(ALT)、直接胆红素(DBIL)、碱性磷酸酶(ALP)、总胆汁酸(TBA)、γ-谷氨酰氨基转移酶(GGT)]、甲状腺功能指标[游离三碘甲状腺原氨酸(FT_(3))、血清促甲状腺激素(TSH)、游离甲状腺素(FT_(4))、三碘甲状原氨酸(T_(3))、甲状腺素(T_(4))]水平并进行比较。结果三组肝功能指标、甲状腺功能指标比较,差异有统计学意义(P<0.05)。其中A组GGT、ALT、ALP、TBA、DBIL、TT_(3)、FT_(3)、FT_(4)、TT_(4)、TSH水平均高于B组、C组,B组GGT、ALT、ALP、TBA、DBIL、TT_(3)、FT_(3)、FT_(4)、TT_(4)、TSH水平高于C组,差异有统计学意义(P<0.05)。结论血清肝功能、甲状腺功能指标水平能有效辅助诊断甲亢性肝病,及时给予患者针对性治疗。Objective To analyze the clinical value of serological indicators in patients with hyperthyroid-related liver disease.Methods A total of 82 patients with hyperthyroid-related liver disease treated at the Second People’s Hospital of Nanyang from May 2022 to December 2023 were selected as group A.Group B consisted of 82 hyperthyroid patients with normal liver function,and group C included 82 healthy individuals from hospital health examinations.Serum liver function indicators[alanine aminotransferase(ALT),direct bilirubin(DBIL),alkaline phosphatase(ALP),total bile acids(TBA),gamma-glutamyl transferase(GGT)]and thyroid function indicators[free triiodothyronine(FT_(3)),serum thyroid-stimulating hormone(TSH),free thyroxine(FT_(4)),triiodothyronine(T_(3)),thyroxine(T_(4))]were measured and compared among the groups.Results There were statistically significant differences in liver function and thyroid function indicators among the three groups(P<0.05).Specifically,the levels of GGT,ALT,ALP,TBA,DBIL,total T_(3)(TT_(3)),FT_(3),FT_(4),total T_(4)(TT_(4)),and TSH in group A were higher than those in groups B and C.Additionally,the levels of GGT,ALT,ALP,TBA,DBIL,TT_(3),FT_(3),FT_(4),TT_(4),and TSH in group B were higher than those in group C,with statistically significant differences(P<0.05).Conclusion Serum levels of liver function and thyroid function indicators can effectively aid in the diagnosis of hyperthyroid-related liver disease and facilitate timely,targeted treatment for patients.

关 键 词：甲亢 肝功能 甲状腺功能 肝损伤 

分 类 号：R743.3[医药卫生—神经病学与精神病学]