天麻钩藤饮联合丁苯酞对急性脑梗死患者症状改善及血管弹性的影响  

Effects of Tianma Gouteng Yin combined with butylphthalide on symptom improvement and vascular elasticity in patients with acute cerebral infarction

作　　者：刘鹏程 方无杰 王晓涛 邓典峰 LIU Pengcheng;FANG Wujie;WANG Xiaotao;DENG Dianfeng(Department of Neurology,Lu'an Hospital of Traditional Chinese Medicine,Lu'an 237000,China;Department of Traditional Chinese Medicine,Ehu Branch of Xishan People's Hospital;Department of Internal Medicine,Ehu Branch of Xishan People's Hospital)

机构地区：[1]六安市中医院神经内科,237000 [2]锡山人民医院鹅湖分院中医科 [3]锡山人民医院鹅湖分院内科

出　　处：《天津医药》2024年第12期1326-1330,共5页Tianjin Medical Journal

基　　金：安徽省重点研究和开发计划项目(1804h08020297)。

摘　　要：目的探究天麻钩藤饮联合丁苯酞(NBP)对急性脑梗死(ACI)患者症状改善及血管弹性的影响。方法纳入六安市中医院82例ACI患者,随机分为单一组和联合组各41例。单一组静脉滴注NBP氯化钠注射液,联合组在单一组基础上辅以天麻钩藤饮进行治疗。比较2组患者入院后1 d(T_(0))及治疗14 d后(T_(1))的脑血管储备功能、血管内皮功能、神经功能、独立生活能力、血流动力学指标、血管弹性、临床疗效及不良反应发生情况。结果T_(0)时2组间脑血管储备功能、血管内皮功能、美国国立卫生院卒中量表(NIHSS)评分、独立生活能力评分、血流动力学指标、血管弹性比较,其差异均无统计学意义(P>0.05)。T_(1)时2组患者的脑血管反应性(CVR),一氧化氮(NO)、一氧化氮合酶(NOS)、大动脉弹性指数(C_(1))及小动脉弹性指数(C_(2))水平均升高,且联合组高于单一组(P<0.05);2组患者的ET-1水平、血管内皮生长因子(VEGF)水平、NIHSS分值、改良Rankin量表(MRS)分值、红细胞压积、全血黏度、血小板黏附率、脉压均降低,且联合组低于单一组(P<0.05)。联合组的治疗总有效率高于单一组,总不良反应发生率低于单一组(P<0.05)。结论天麻钩藤饮联合NBP可有效改善ACI患者的脑血管储备功能、血管内皮功能以及神经功能损伤,增加血管弹性,提高血流动力学水平。Objective To explore the effect of Tianma Gouteng Yin combined with butylphthalein(NBP)on symptom improvement and vascular elasticity in patients with acute cerebral infarction(ACI).Methods Eighty-two ACI patients admitted to Lu'an Hospital of Traditional Chinese Medicine were included in this study,and they were randomly separated into the single group and the combination group,with 41 cases in each group.The single group was given intravenous infusion of NBP sodium chloride injection,and the combination group was given treatment with Tianma Gouteng Yin on the basis of the single group.Cerebrovascular reserve function,endothelial function,neurological function,independent living ability,hemodynamic indicators,vascular elasticity,clinical efficacy and incidence of adverse reactions were compared between the two groups of patients at 1 day after admission(T_(0))and 14 days after treatment(T_(1)).Results There were no significant differences in cerebrovascular reserve function,endothelial function,National Institutes of Health Stroke Scale(NIHSS)scores,independent living ability scores,hemodynamic indicators and vascular elasticity indicators at T_(0) between the two groups(P>0.05).At T_(1),levels of cerebrovascular reactivity(CVR),nitric oxide(NO),nitric oxide synthase(NOS),large artery elasticity index(C_(1))and small artery elasticity index(C_(2))were significantly increased in both groups,and levels were higher in the combined group than those of the single group(P<0.05).At T_(1) moment,levels of ET-1,vascular endothelial growth factor(VEGF),NIHSS score,MRS score,red blood cell count,whole blood viscosity,platelet adhesion rate and arterial pressure were reduced in both groups,and levels were lower in the combined group than those of the single group(P<0.05).The total effective rate was higher in the combination group(80.5%)than that of the single group(46.3%).The overall incidence of adverse reactions was lower in the combined group than that in the single group(P<0.05).Conclusion Tianma Gouteng Yin combined w

关 键 词：脑梗死 天麻钩藤饮 丁苯酞 症状改善 血管弹性 

分 类 号：R743.33[医药卫生—神经病学与精神病学]