丁苯酞联合多奈哌齐对血管性痴呆患者认知功能及脑血管储备功能的影响  

The impact of butylphthalide combined with donepezil on cognitive function and cerebrovascular reserve in patients with vascular dementia

作　　者：潘晓丹 Pan Xiaodan(People's Hospital of Xinyi City,Maoming,Guangdong 525300,China)

机构地区：[1]广东省信宜市人民医院,广东茂名525300

出　　处：《首都食品与医药》2024年第23期73-76,共4页Capital Food Medicine

摘　　要：目的 探讨丁苯酞联合多奈哌齐对血管性痴呆患者认知功能及脑血管储备(CVR)功能的影响.方法 选取2023年1月-2024年1月我院收治的血管性痴呆患者78例,分为三组,对照组选择基础治疗,观察1组在基础治疗上叠加使用多奈哌齐治疗,观察2组在基础治疗上使用丁苯酞及多奈哌齐治疗.结果 治疗后观察1组、观察2组MMSE评分、MOCA评分均高于对照组(P<0.05),观察2组MMSE评分、MOCA评分均高于观察1组(P<0.05);观察1组、观察2组ADL评分、BHI评分均高于对照组,CDR评分均低于对照组(P<0.05),观察2组ADL评分、BHI评分均高于观察1组,CDR评分低于观察1组(P<0.05);观察1组、观察2组血液黏度、低切黏度、中切黏度、高切黏度、红细胞比积、红细胞聚集指数均低于对照组(P<0.05),观察2组血液黏度、低切黏度、中切黏度、高切黏度、红细胞比积、红细胞聚集指数均低于观察1组(P<0.05).结论 血管性痴呆患者治疗中,叠加多奈哌齐治疗相较于基础治疗,能够有效改善患者的痴呆症状,恢复认知功能,改善血液流变学指标,恢复脑血管储备功能,提高日常生活能力,而使用丁苯酞联合多奈哌齐治疗,相较于仅叠加多奈哌齐药物,上述各方面治疗成效更为优良,改善、恢复更为显著.Objective To investigate the impact of butylphthalide combined with donepezil on cognitive function and cerebrovascular reserve(CVR)in patients with vascular dementia.Methods A total of 78 patients with vascular dementia treated in our hospital from January 2023 to January 2024 were selected and divided into three groups.The control group received basic treatment,observation group 1 received donepezil in addition to basic treatment,and observation group 2 received both butylphthalide and donepezil in addition to basic treatment.Results The MMSE and MOCA scores of observation groups 1 and 2 were higher than those of the control group(P<0.05),and those of observation group 2 were higher than those of observation group 1(P<0.05).The ADL and BHI scores of observation groups 1 and 2 were higher than those of the control group,and their CDR scores were lower(P<0.05).The ADL and BHI scores of observation group 2 were higher than those of observation group 1,and the CDR scores was lower(P<0.05).Blood viscosity,low shear viscosity,medium shear viscosity,high shear viscosity,hematocrit,and erythrocyte aggregation index were lower in observation groups 1 and 2 than in the control group(P<0.05),and the blood viscosity,low shear viscosity,medium shear viscosity,high shear viscosity,hematocrit,and erythrocyte aggregation index were lower in observation group 2 than in observation group 1(P<0.05).Conclusion In the treatment of vascular dementia patients,adding donepezil to the basic treatment can effectively improve dementia symptoms,restore cognitive function,improve hemorheological indices,restore cerebrovascular reserve function,and enhance daily living ability.Treatment with butylphthalide combined with donepezil is more effective in these aspects compared to using donepezil alone,leading to more significant improvement and recovery.

关 键 词：丁苯酞 多奈哌齐 联合治疗 血管性痴呆 认知功能 脑血管储备功能 

分 类 号：R743[医药卫生—神经病学与精神病学]