网络游戏障碍患者大脑半球水平动态功能连接异常的功能磁共振成像研究  

Functional magnetic resonance imaging study on abnormal dynamic functional connectivity of cerebral hemisphere in patients with internet gaming disorder

作　　者：马泷耀 张勇[1] 张孟哲 牛晓玉 康依蒙 汪卫建 程敬亮[1] Ma Longyao;Zhang Yong;Zhang Mengzhe;Niu Xiaoyu;Kang Yimeng;Wang Weijian;Cheng Jingliang(Department of MRI,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China)

机构地区：[1]郑州大学第一附属医院磁共振科,郑州450052

出　　处：《中华行为医学与脑科学杂志》2024年第11期967-973,共7页Chinese Journal of Behavioral Medicine and Brain Science

基　　金：河南省重点研发与推广专项(科技攻关)项目(212102310712)。

摘　　要：目的探讨网络游戏障碍(internet gaming disorder,IGD)患者脑功能网络的动态时间变异性。方法2019年1月至2021年12月,收集符合诊断标准的55例IGD患者(IGD组)以及人口资料相匹配的50例健康对照者(健康对照组)静息状态功能磁共振成像数据。使用IBM SPSS 21.0进行数据分析。使用功能连接密度结合滑动窗分析方法计算全脑功能连接密度的时间变异性,再将全脑功能连接密度分为同侧和对侧部分。之后进一步采用全脑、半球内和半球间功能连接密度的标准差来量化动态功能连接密度(dynamic functional connectivity density,dFCD)的时间变异性。最后,提取差异脑区dFCD值与临床特征进行Pearson相关分析。结果IGD患者在左侧后扣带回(-0.16±0.24)和左侧楔前叶(-0.08±0.23)表现出半球间dFCD的值低于健康对照组(0.002±0.260,0.12±0.36)(t=-3.502,-4.160,均P<0.05)。IGD患者在左侧距状沟、左侧楔前叶和左侧后扣带回半球内dFCD低于健康对照组(t=-3.809,-4.360,-3.561,均P<0.05)。左侧距状沟全脑dFCD和左侧后扣带回半球内dFCD与IGD患者的严重程度呈负相关(r=-0.380,-0.413,均P<0.05)。结论IGD患者在视觉注意网络与默认模式网络中的半球内和半球间动态功能连接存在异常,这可能反映了IGD患者存在认知障碍与注意力受损的潜在神经生物学机制。ObjectiveTo explore the dynamic temporal variability of brain functional networks in individuals with internet gaming disorder(IGD)using dynamic functional connectivity density(dFCD).MethodsFrom January 2019 to December 2021,resting-state functional magnetic resonance imaging data were recruited from 55 patients with IGD and demographically matched 50 healthy controls.Data analysis was performed by IBM SPSS 21.0 software.The functional connectivity density(FCD)combined with sliding window analysis was employed to calculate the temporal variability of global functional connectivity.FCD in whole brain was further devided into ipsilateral and cotralateral parts.The temporal variability of dFCD was further quantified utilizing the standard deviations of whole brain,intra-,and inter-hemispheric FCD.Finally,Pearson correlation analysis was performed between dFCD variance in differential brain regions and clinical behaviors.ResultsThe inter-hemispheric dFCD in the left posterior cingulate cortex(-0.16±0.24)and the left precuneus(-0.08±0.23)in patients with IGD were lower that those in healthy controls(0.002±0.260,0.12±0.36)(t=-3.502,-4.160,both P<0.05).And the intra-hemispheric dFCD in the left calcarine,the left precuneus,and the left posterior cingulate cortex in patients with IGD were lower that those in healthy controls(t=-3.809,-4.360,-3.561,all P<0.05).Moreover,abnormal global dFCD variability of the calcarine and ipsilateral dFCD variability of the PCC negatively correlated with the severity of IGD(r=-0.380,-0.413,both P<0.05).ConclusionPatients with IGD show intra-and inter-hemispheric dFCD differences in the visual attention network and default mode network,which may respond to the underlying neurobiological basis for the presence of cognitive dysfunction and impaired concentration.

关 键 词：网络游戏障碍 成瘾 动态功能连接密度 功能磁共振成像 全脑 半球内 半球间 

分 类 号：R749.99[医药卫生—神经病学与精神病学]